Thirteen cases of early gastric cancer which had over 1.5cm in diameter and/or submucosal invasion and/or with ulcerative changes were treated by YAG-Laser plus OK-432 (one of Biological Response Modifier: BRM) injection endoscopically
Of the patients four were over 80 years old, other 9 patients had heavy concurrent diseases.
Macroscopic classification of the gastric cancers were as follows; IIc 5 cases, IIc+III 6 cases, IIa one case and III+IIc one cases.
Four invased only in mucosal layer and the others invased in submucosal layer endoscopically.
OK-432 was injected 10KE around a laser ulcer in 1-2 times per week totally 80KE-200KE (10KEX8-20).
In 8 cases of them, biopsies were negative by endoscopic controlls in 3-62 followed months (mean 16 months). One patient refused treatment on the way. One was operated because of new lesion, one was died by concurrent disease during the treatment period. Two were re-treated because of local recurrence.
Though our small group and short follow up period, we think this combined method is useful for inoperable early gastric cancer.
