Abstract
Temperature rise of KK-47 bladder tumors transplanted into nude mice, 200 to 300mm was determined at an average output of 150mW/cm2 (9J/cm2/min) or 300mW/cm2 (18J/cm2/min) with a gold vaporlaser (GVL). Approximately 43°C hyperthermia of the entire tumor was attained with the 300mW/cm2 output.
After 10mg/kg HpD injection, GVL-photoradiation and concomitant GVL-induced hyperthermia achieved CR (complete remission) in 6 of 6 tumor-bearing nude mice at 3, 7.5, 15 and 30 minute-irradiation times.
With decreasing HpD dosage ranging from 10 to 5mg/kg, CR rate was decreased at all the irradiation times. However, analysis of the tumor growth curves of two groups received HpD 1 or 2.5mg/kg and control groups without HpD demonstrated that HpD resulted in a significant reduction of the GVL-induced hyperthermia antitumor effects.
