Studies on ablation efficiency with Hematoporphyrin Derivatives for atheromatous lesion

Abstract

This studies were performed on the possibility of safety making atherosclerotic foci regress with photodynamic therapy (PDT) using Hematoporphyrin Derivatives (HpD), as a photosensitizer. Atherosclerotic rabbits, whose atherosclerotic lesions in the aorta were induced by 2% cholesterol diet and by balloon damage, were divided into two groups, that is, group C and group H. The group C is consisted of rabbits nontreated with HpD and the group H treated with HpD. The argon laser introduced by fiber was irradiated on the athromatous lesion of abdominal aorta in vitro for 1sec-180sec, and the power was 100mW-2000mW. The aorta was dissected for histological study. Group H atherosclerotic lesions were vaprized by lower energy and shorter time level than in group C.
From the above data, it is suggested that PDT may be effective for treatment of atheromatous lesion of artery.