Abstract
The effect of Excimer Dye Laser (EDL) on photodynamic therapy (PDT) for brain tumor has been investigated in glioma model, established by implanting C6 cells in Wistar male rat and induced by ENU. The anti-tumor effects were studied histologically and evaluated measuring the size of tumor necrosis (depth×width) after the therapy in comparison with concentration of HpD (2, 5, 10mg/kg), frequency of repetition (30, 40, 60Hz), and pulse energy (0.5, 1.0, 2.0, 4.0mJ). Consequently, EDLPDT resulted in as follows; the size of tumor necrosis was closely correlated with concentration of HpD and total light dose, while it was inversely correlated with pulse energy. The histological examination suggested that EDL has higher selection to tumor tissues rather than normal brain tissues. Especially, in border zone between tumor and normal brain tissues 1.0-2.0mJ of pulse energy seemed to be more favorable to the tumor selection. There were no severe adverse effects in EDL-PDT.
