Photodynamic Therapy (PDT) for the local administration of Hematoporphyrine Derivative (HpD) Using A Dispatch Catheter

Abstract

Recently, the effects of photodynamic therapy (PDT) on atherosclerosis using Herine derivative (HpD), a photosensitive material, have been reported. However its clinical use has been limited due to photodermatosis, a side effect of HpD. the purpose of this experiment was to suppress the occurrence of photodermatosis by local administration of minimal dose HpD. 5mg of HpD was applied to the atherosclerotic lesion on the aorta of each rabbit through a Dispatch catheter.
The lesions were then exposed to 200mw output YAG-OPO laser beam at 630nm for 10 minutes from the intimal side of the aorta. As expected, the intimal region irradiated by laser became thinner compared with the non-irradiated region. PDT and non-PDT groups were expressed in terms of JIM ratio (intimal thickness/medial thickness). Results are the presented as mean ± S. D. The JIM ratio of PDT group was 2.38 ± 0.55, while that of non-PDT groups was 4.09 ± 0.49
A Dispatch catheter enabled the atherosclerotic lesions to absorb enough amount of HpD for PDT.