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Volume 18, Issue 4
Displaying 1-8 of 8 articles from this issue
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Mitsuhiko NAKAMURA1997 Volume 18 Issue 4 Pages 3-14
Published: 1997
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSAs parts of a basic study of photodynamic therapy on hepatic tumor, the effect of an optical parametric oscillator pumped by Q-switched YAG laser (YAG-OPO Laser, model iLS-TL-50A, Ishikawajima-Harima Heavy Industries (IHI), Tokyo) that is a newly developed tunable laser, combined with a photosensitizer PH-1126, was evaluated. PH-1126 was intervenously administered at 3 mg/kg b. w. into model Japanese white rabbits, which had been prepared by implanting VX2 tumor cells into the liver. At various time intervals after the administration of PH-1126, the concentration of it accumulated in hepatic tissue and tumor mass was determined using high-performance liquid chromatography (HPLC). PH-1126 concntration in tumor mass 48 hours after administration was 34.3±0.22 μg/g, which was approximately 1.5times that in normal hepatic tissue. It indicats that 48 hours post-administration was the optimum time for irradiation. YAG-OPO laser beam with a wavelength of 650nm and mean output of 100mW/cm2 was applied at 150J/cm2 to tumors 48 hours after PH-1126 administration. The application raised tissue temperatue by approximately 3°C without causing any thermal damege. The photodynamic therapy inhibited tumor growth and more over exhibited additional significant anti-tumor effects including 1) intrahepatic metastasis inhibitory effect and 2) pulmonary metastasis inhibitory effect.View full abstractDownload PDF (52679K) -
Hiraku YODONO, Hiroshi NODA, Atsushi SHINOHARA, Shuichiro ABE, Yoko SA ...1997 Volume 18 Issue 4 Pages 15-20
Published: 1997
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSPURPOSE: To assess the results of laser angioplasty combined with thrombolysis by intraarterial infusion of urokinase for complete occlusions of the pelvic and lower limb arteries.
MATERIALS AND METHODS: Since 1986 through 1995, 41 of complete occlusion cases were treated with PTLA combined with thrombolysis by intraarterial infusion of urokinase. All patients were in high risks group and considered inoperable. 1060nm CW Nd: YAG laser was used for PTLA and two types of laser probe were used for laser irradiation by contact method, and various types of angioscopy were used for assessment before and after laser irradiation. Urokinase was directly infused into the thrombi in wedge state at the rate of 1-2×104 units/min.. The total doses of urokinase were ranged from 6 to 90×104 units. Conventional balloon dilatation was added after the procedure, if needed.
RESULTS: Angioscopy was useful in differentiating atheromatous lesions from thrombi and has contributed in planning how to treat the lesions. Occlusive arteries were recanalized in 31 of 41 cases with satisfactory results, the initial success rate was about 76%. The 1-year cumulative patency rate of complete occlusive lesions was about 67%, 2-year 60%, 3-year 50%and 5-year 46%. Complications such as distal embolism, dissection and others were noted.
CONCLUSIONS: PTLA combined with thrombolysis is very useful in treating occlusion of arteries.View full abstractDownload PDF (20485K) -
Shunichi HOSHINO, Hirofumi MIDORIKAWA1997 Volume 18 Issue 4 Pages 21-29
Published: 1997
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSThe combination therapy of laser angioplasty (LAP) and another interventional treatment has been performed on 80 atherosclerotic lesions in 56 patients from June 1989 through June 1997 in our department of Cardiovascular surgery. From the short and long term results, the suitable indication for LAP seemed to be an occlusive arterial disease with a iliac lesion less than 5cm in length and a femoropopliteal lesion less than 10cm. For the improvement of clinical results, it was important to perform adjunctive directional atherectomy and stent instead of balloon angioplasty. LAP could increase the indication for endovascular surgery, because LAP could be carried out to complete occlusive and severe stenotic lesions. In the future, we will expect the further development of laser system for angioplasty, and improvement of the clinical results.View full abstractDownload PDF (53081K) -
Masayoshi OKADA1997 Volume 18 Issue 4 Pages 31-39
Published: 1997
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSWith an increase of the number of patients with ischemic heart disease several kinds of therapies such as PTCA, coronary stenting and coronary artery bypass surgery (CABG) have been widely performed even in Japan.
However, there are a few patients for whom CABG can not be carried out at all, because small branches and diffuse stenotic lesions of the coronary arteries.
For those patients we have planned to supply arterial blood from the left ventricular cavity into the ischemic myocardium through laser channels created by CO2, laser (TMLR).
Based on our excellent experimental studies TMLR was applied in a 55 year old male patient with severe anginal attack. This patient was a first successfull clinical case treated by TMLR alone in the world.View full abstractDownload PDF (40544K) -
Hajime NAKANO, Yoshimasa YABE1997 Volume 18 Issue 4 Pages 41-54
Published: 1997
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSUsing a Holmium YAG (wave length 2.08μm) and Thulium YAG (wave length 2.01μm) laser generator with 1.5 to 1.75mm multiple quartz fiber catheter, Ho: YAG laser angioplasties were attempted at 0.3 msec pulse width, 10Hz repetition rate, 1 to 2sec laser delivary time. Tm: YAG laser angioplasties were attempted to same conditions except 0.5 msec pulse width.
I. Ho: YAG laser coronary angioplasty.
Laser success was achieved in 56% (10/18). Overall laser-assisted balloon angioplasty success was observed in 18 of 18 lesions (100%).
II. Tm: YAG laser coronary angioplasty.
Laser success was achieved in 65% (11/17). Overall laser-assisted balloon angioplasty success was observed in 17 of 17 lesions (100%).
Major complications were not observed in both group. Restenosis rate after laser-assisted balloon angioplasty was 17% (3/18) in Ho: YAG group and 18% (3/17)in Tm: YAG group. From above figures mid-infrared pulsed laser (Ho: YAG and Tm: YAG) coronary angioplasties were safety and effective.View full abstractDownload PDF (69946K) -
Tomitsugu KATOH, Ken TAMURA, Atsuko SASAME, Hitoshi NAKAJIMA, Tadashi ...1997 Volume 18 Issue 4 Pages 55-60
Published: 1997
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSRecently, the effects of photodynamic therapy (PDT) on atherosclerosis using Herine derivative (HpD), a photosensitive material, have been reported. However its clinical use has been limited due to photodermatosis, a side effect of HpD. the purpose of this experiment was to suppress the occurrence of photodermatosis by local administration of minimal dose HpD. 5mg of HpD was applied to the atherosclerotic lesion on the aorta of each rabbit through a Dispatch catheter.
The lesions were then exposed to 200mw output YAG-OPO laser beam at 630nm for 10 minutes from the intimal side of the aorta. As expected, the intimal region irradiated by laser became thinner compared with the non-irradiated region. PDT and non-PDT groups were expressed in terms of JIM ratio (intimal thickness/medial thickness). Results are the presented as mean ± S. D. The JIM ratio of PDT group was 2.38 ± 0.55, while that of non-PDT groups was 4.09 ± 0.49
A Dispatch catheter enabled the atherosclerotic lesions to absorb enough amount of HpD for PDT.View full abstractDownload PDF (30337K) -
Junichi HAYASHI, Takashi SAITO, Akira KANEDA, Katsuo AIZAWA1997 Volume 18 Issue 4 Pages 61-65
Published: 1997
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSAdvances in three main factors, which are photosensitizers, laser equipments and fluorescence detectors, develope photodynamic diagnosis and therapy in the fields of canser research and vascular medicine. A new photosensitizer, mono-L-aspartyl chlorin e6 (NPe6), accumulates in atheroma and emitts fluorescence at 672nm by irradiation of laser at 664nm. Atheroma is diagnosed using the high sensitive fluorescence detector with a selective band pass filter and treated by laser irradiation with high tissue fluence. Indication of photodynamic diagnosis and therapy now spreads to the atherosclerotic diseases.View full abstractDownload PDF (23807K) -
Masami SAKURADA, Takayuki MIYAKE, Tsunenori ARAI, Miya YOSHIKAWA, Mako ...1997 Volume 18 Issue 4 Pages 67-74
Published: 1997
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSWe developed a novel laser-heated hot balloon catheter. We investigated the optimal heating duration and temperature in animal models in vitro and in vivo. Deep heat injury by high temperature or long-term heating caused intense intimal proliferation. The optimal heating duration and temperature for normal rabbit iliac artery was 70°C and 15 seconds. Short-term thermal ballon angioplasty may be effective to prevent restenosis following PTCA.View full abstractDownload PDF (38220K)
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