Abstract
It is reported that hydroquinone-tretinoin (HQ-T) ointment is effective for chloasma, chemical peeling, and pre-/post-treatment of inflammatory skin pigmentation due to laser resurfacing.We have employed steroid therapy, including 10% of hydroquinone, for refractory chloasma and post-laser inflammatory pigmentation. It has been said that the action of hydroquinone would be increased by adding tretinoin. We therefore studied the effects for dyschromatosis (such as chloasma) given 5% hydroquinone creams with 0.1% tretinoin, consisting of inflammatory pigmentation after skin resurfacing treatment due to ultra-pulse laser, or senile pigmented spots due to Q-switch ruby laser. These agents which are unauthorized in Japan, were only employed on subjects who had given their voluntary consent. They were given for 3 weeks before laser therapy, and during a 3 month period commencing 3 weeks after laser therapy. The clinical results were evaluated.
