Photoradiation therapy with protoporphyrin disodium for human hepatocelluar carcinoma transplanted nude mice

Abstract

In the present report, we studied about in vivo anti-tumour effect by photoradiation therapy (PRT) with proroporphyrin disoduim (PPNa) and hematoporphyrin derivative (HpD). To investigate anti-tumour effect by PRT, human hepatocellular carcinomas transplanted to the flanks of BALB/c/nu nu mice were injected intratumorrally 2 mg of HpD, PPNa or 0.9% NaCl 48 hours before laser irradiation (514.5nm, 0.1w, 30 minutes.) The results revealed that laser irradiation alone had no anti-tumour effect, while PRT with PPNa had intense anti-tumour effect (p<0.05) more than PRT with HpD. These results showed that PRT with PPNa may have clinical use.