Abstract
Photoradiation therapy (PRT) is a recently introduced treatment for malignant Neoplasms, which depends on the tumor localization and retention of Hematoporphyrin derivative (HpD) activated by a proper light in the presence of oxygen.
PRT in combination of 50, 100, 150, 200mW power of Argon-pumped dye laser and 5, 10, 50μg/ml concentration of HpD can completely kill T9 cells in culture, and is effective to elongation of mean survival time of rat brain tumor models which were innoculated 105-6 T9 cells in the right parietal lobe.
(Control n=39 28.18±2.95 days, PRT n=4 41.0±7.97 days P<0.01)
The important side effect of PRT is considerable brain edema, so we should have a care for its clinical application.
