Abstract
We studied localized hyperthermia using contact Nd:YAG laser irradiation for tumors on nude mice, which were performed transplantion of anaplastic cell carcinoma obtained from human thyroid lesion. Twenty nude mice were divided into four groups; laser hyperthermia, cisplatin (CDDP) therapy, laser hyperthermia combined with CDDP and control. The new type of ceramics laser rod for localized hyperthermia was devised and used for transplanted tumors on animals. CDDP, 2.4mg/kg, was injected intraperitoneally each subject on the day before laser hyperthermia.
The interstitial laser hyperthermia was carried on for 20 minutes between 41.5 and 43°C. The results showed that laser hyperthermia combined with CDDP was most effective for inhibition of tumor growth in size. Laser hyperthermia without CDDP did not obtain so satisfactory treatment effect, as compared with combination therapy.
We applied this new method to eleven clinical cases with head and neck cancers Laser hyperthermia combined with radiochemotherapy reduced all malignant tumors.
We believe this new method of interstitial laser hyperthermia will be useful for treatments of head and neck cancers.
