Abstract
Since 1978, our group has examined porphyrin derivatives based on hemoglobin and chlorophyll and their metal complexes (200 in all) through the cooperation of Sakata et all, of Toyohakka Kogyo. We have previously found and reported that side chain structure and tumor tissue accumulation are related.
Based on the datas obtained, our study now been forcused on making the following substances available.
a) Bacterio-pheophorbide (λ=755nm) which has an absorption band shifted to longer wavelength than that of HPD or DHE, so that deeper tissue penetration of photo-radiation can be achieved.
b) Highly tumor-seeking radiopharmaceuticals for scintigraphic studies that have advantages over Ga-67 citrate which is used clinically in the world.
c) New cancer-targetting anti-tumor chemicals which have accumulate and remain in cancer tissue.
In this congress, I would like to report our results of investigation.
