Experimental studies on photochemotherapy

-Comparison between intratumoral injection and systemic injection of HpD-

Abstract

We investigated the anti-tumoral effect of intratumoral injection using nude mice with subcutaneously transplantated MKN-45 gastric cancer followed by exposure to red light in order to avoid phototoxic reaction after intravenous administration of hematoporphyrin derivatives (HpD). Histopathological findings revealed that necrosis was uniform in the group administered intraperitoneally but it was not so in the group administered intratumorally. We conclude that anti-tumoral effect of intraperitoneal injection was superior to that of intratumoral injection but still significant even in the intratumoral injection, based on the results of calculated the necrotic volume(%) by means of Kontron MOP-AM03 instrument in each group.