Abstract
The author conducted various experiments placing the emphasis on the detection of Br-vanillic acid, ethereal sulphate or glucuronids. Simultaneously, the toxicity of Br-vanilline was compared with that of vani (line, thus the significance of brominization was studied. From the pathological and histological findings of liver of rabbit administered with Br-vanilline in an attempt to estimate the grade of the toxicity of Br-vanilline.
1) From the urine of rabbits administered with Br-vanilline, crystals of a glucuronid-like substance of Br-vanillinic acid (C14H15O10Br) possessing the melting point of 225°-230°C (with decomposition) were isolated.
2) The ethereal sulphate content of the urine of rabbit administered with Br-vanilline remarkably increased.
3) The ethereal sulphate content of the urine of rabbit administered with salicylaldehyde or salcylamine also clearly increased.
4) Br-vanilline is less toxic than vanilline in mice.
5) The pathological histoiogical findings in the liver of rabbit administered with Br-vanilline is relatively mild.
