Abstract
Following Togami's studies, the author investigated the influences of the splenic cornponents of various animals, especially of cattle, on the experimental hepatic disturbances in mice induced by carbon tetrachloride. In view of Togami's report that tyrosine-like substance contained in the splenic components of cattle possesses a strong inhibitory action against hepatic disturbances, experiments with the combination of splenic components with tyrosine were also conducted. Experiments with leucine and methionine were also performed.
1) The hepatic disturbances intmice intoxicated by carbon tetrachloride was inhibited, though slightly in degree, by the alcohol soluble extract of dehematized spleen of cattle.
2) In the case of application of the combined (A), (B) and (C) solutions isolated from the alcohol insoluble fraction of the splenic components of cattle, fairly strong inhibitory action on the hepatic disturbances was recognized.
3) In the case of application of the combination of splenic components with 1-tyrosine, the inhibitory action became marked, and the splenic components promoted the inhibitory action of 1-tyrosine.
4) In the cases of 1-leucine and dl-leucine, no inhibitory action was recognized, and even with the combination with splenic components, no marked promoting action was recognized.
5) The inhibitory action of methionine, especially of 1-methionine was intense. In the case of application of combination with splenic components, the inhibitory action became further stronger.
