Abstract
The present knowledge concerning the absorption of histamine in the large intestine cannot be regarded as complete as yet. In parallel with Honda's experiments concerning the absorption of histamine in the small intestine, the author investigated the absorption of histamine in the large intestine and the influence of various substances thereon. In the present paper, aminoacids, sugars, calcium chloride, cattle bile and “ Sprase ” were firstly dealt with as the substances administered in combination with histamine. Further, the influence of pH on the absorption of histamine in thej large intestine was also studied. As the result, the following conclusions were drawn.
Though almost no absorption of histamine hydrochloride in the large intestine is recognized at the room temperature of 14.0°-28.0°C when administered alone, the influence of higher room temperatures thereon cannot be ignored. The absorption in the large intestine is observed when the room temperature rises to 31.0°-32.5°C. When the histamine solution is on the acid side, a slight enhancement of the absorption of histamine in the large intestine is recognized contrary to the case when the histamine solution is on the alkaline side. As it is in the case of the absorption of histamine in the small intestine, the absorption of histamine in the large intestine is most remarkably enhanced when histamine is administered in combination with cattle bile.
