Abstract
In the present paper, the author investigated the influence of various splenic components of various animals on the agglutinin production in the rabbits. Further, the author conducted similar experiments with aromatic aldehydes, furan aldehydes, and a few aminoacids, which possess inhibitory action against the damages in the liver, thereby attempted to elucidate the significance of the combined administration of the splenic components and various substances described in the above, which had been conducted by various workers.
As the results of the above experiments, the presence of the agglutinin production promoting substances in the spleen of various animals, especially of cattle and hog, was confirmed, though the isolation of the fraction exercising a particularly strong action was unsuccessful. Nevertheless, it was learnt that, combined administration of alcohol-soluble and -insoluble fractions of cattle spleen and the leucine-like substance isolated from the same spleen most remarkably promotes the active immunization. Furthermore, in view of the fact that dl-leucine, 1-tyrosine, salicylaldehyde, benzaldehyde, vanillin, acetyl-oxymethylfurfural possess the active immunization promoting action, the administration of splenic components combined with these substances was considered to have a specific significance to the living subjects.
