Abstract
The author injected dihydrostreptomycin and potassium iodide into fertilized hen's eggs, and conducted histopathological examinations on the heart and kidney of the chick embryo on the 12 th, 15 th and 18 th days of incubation. The following results were thus obtained.
1) Findings in the heart : In the initial stage of the incubation single injection of streptomycin or potassium iodide caused the enlargement and proliferation of the pericardiac endothelial cells; with the combined administration, cell infiltration of the pericard was observed. Further, in the terminal stage of the incubation, the single injection of streptomycin or potassium iodide gave rise to cell infiltration of pericard; with combined administration, the enlargement and proliferation of the endocardiac endothelial cells were recognized. Furthermore, no particular findings except blood vessel congestion were recognized in the myocard.
2) Findings in the kidney : In the single injection of streptomycin or potassium iodide and also in the injection of the combination of these two drugs in the initial stage of incubation, the hyperemia and cell infiltration respectively in the glomerulus was observed. Particularly in the single injection, thickening of the Bowman's capsule was recognized. Furthermore, the degeneration of the urinary tubuli was recognized more eminently in the combined injection than in the single injection. In the terminal stage of incubation, cell infiltration in the glomerulus was recognized in the single injection as well as in the combined injection. Moreover, degeneration in the urinary tubuli was recognized in the single injection of potassium iodide and combined injections.
