ペニシリン過敏症の2例

抄録

Injections of 300, 000-600, 000 units of penicillin procain sol were given to a case of acute cystitis and to another case of acute mastitis. Both of the cases collapsed 30 seconds after the injection, and demonstrated serious symptoms such as agony in the chest, accelerated pulsation, dyspnea, soft pulsation, turbidity of consciousness, general convulsion, measles-like redness on the face, extremities and trunk and hyperemia of conjunctiva. Fortunately, both cases escaped from unfavorable outcome.
Although the essence of the allergic response is still unknown, the author advocates a special attention to the patients' constitution, especially in those cases with disturbed balance of autonomous nervous system, specifically with parasympathetic nervous system tonous constitution of allergic constitution, or those cases experienced idiosyncrasy reaction such as asthma or other allergic diseases. The author also stresses the necessity to avoid the abuse of penicillin preparations, attention to the patients' constitution and intradermal reaction with small dosis as prophylactic measures. No other treatments than symptomatic ones are known. Heart stimulant, respiration stimulant, adrenalin and adti-eistamine drugs are recommended. Componsation of body fluid by Ringer solution and glucose injections are also recommended.