抄録
The blood-brain barrier, which is presumed to exist in the central nervous system, fails due to oxygen defficiency under low pressure. As one of the experimental means to grasp this failure histologically, obervations in the present work were focused at the disturbances in the perivascular structures. Becker's Astraviolett FF was employed as indicator and the regions coloured by it were described and histologically examined principally by means of PAS and various silver mpregnation methods.
White rats and guinea pigs were placed for varying period under 1/4-1/7 atmospheric pressure, and Astraviolett FF solution was introduced thereafter. Then, they were irrigated with physiological saline solution. Various regions coloured by Astraviolett FF thus. discovered were taken as the regions where the blood-brain barrier failed. They were cortex of of cerebellum, Ammon's horn, cortex of cerebrum, infundibulum and the basis of the 4 th ventricle. In addition to the acute swelling of the nerve cells, disturbances in the perivascular structures and in the capillaries were observed as the histological pictures of these regions. In other words, Lamina acc. ext. of the small and medium sized blood vessels was found bulging toward outside and frayed, and the fenestration and the mesh work were found fused. The affinity of the capillary wall to PAS and silver was found lost.
