Abstract
The phagocytic action of neutrophilic leucocytes and hematologic changes were studied in Wistar albino rats. Experimental animals were divided into six groups ; such as 1. control, 2. adrenalectomized bilaterally, 3, adrenalectomized and received cortisone 25 mg/kg daily, 4. adrenalectomized and received DOCA 5 mg/kg daily, 5. received cortisone 25 mg/kg daily and 6. received 5 mg/kg DODA daily the following results were obtained.
1. In adrenalectomized rats, the phagocytic action was increased slightly, but it reduced by the administration of cortisone, while by the administration of DOCA showed no effect on it.
2. In the control rat the phagocytic action was reduced slightly by the administration of cortisone, while it increased by DOCA.
3. The number of leucocytes in adrenalectomized rats decreased by the administration of cortisone, while it did not influenced by any other agents used in this experiment.
4. The remarkable lymphopenia was observed in adrenalectomized rats by administration of cortisone, while lymphopenia in control rats was mild by curtisone treatment.
5. A marked eosinophilia observed in abrenalectomized rats was inhibited by DOCA, and elevated by cotisone treatment.
It is suggested by the above observation that the phagocytosis in rats is decreased by cortisone and increased by DOCA treatments.
