Abstract
1. The highest blood level of various organs was observed on the 5th hour after per os administration of Oleandomycin (OM) on rats. Generally, its concentration in the blood, liver, lung and kidney was fairly high. In young rats, however, in spite of the use of the same amount of OM per kg, its cocentration and duration was low and short in comparison with that of adult rats. This tendency was also observed when Triacetyl OM was administered per os and when OM was administered intravenously.
2. Generally, the concentration of OM in various organs was high when administered per Os at the time of septicemia. Its absorption, however, was poor at the time of Chlorpromazine or Pentabarbital application. In the case of Cortisone administered intramuscularly, the absorption of OM was excellent in the primary stage, and, moreover, when hepatic functions were disturbed by CCl4, the absorption of OM became high in various organs.
3. In rabbits, the transmission of OM administered per os was excellent into the blood as well as into the vaginal fluid, and in many cases, its concentration in the vaginal fluid was higher than that in the blood. In young rabbits, in spite of the use of the same amount of OM per kg, the concentration was low both in the blood and the vaginal fluid, and the duration of its presence in various organs too was short.
4. Intramuscular administration of Synahorin, Ovahormon, or Oephorminlutun showed no appreciable influence on the concentration of OM in the blood, vaginal fluid and various organs. While, its concentration was enhanced when Cortate or Enarmon was administered instead. Especially, this tendency was remarkable on the vaginal fluid at the time of Enarmon injection.
5. The highest blood level of OM was seen on the 2nd hour after per os administration on adults, and it was observed 15-30 minutes after intravenous administration. Its concentration in the mother's milk became higher than that in the blood from the 2th hour, and in most cases, the concentration in the vaginal fluid also became higher. This tendency was especially remarkable when there was some uterine disorder.
6. The transmission of OM into the chorionic tissue, uterus, oviduct, uterine myoma and ovarian was also recognized, but their OM concentration was much lower than that of the blood.
7. Per os or intravenous administration of OM was found to be effective for the treatment of infectious diseases in the field of gynecology, especially, those in which staphylococci were the causative microorganisms.
8. Intravaginal application of OM (in a daily dose of 100 mg) continued for 4 to 5 days was also found to be highly effective for the treatment of various infectious diseases in the field of gynecology.
