Abstract
The depolymerization of connective tissue was proved histochemically in scurvy, and the fluctuation of serum glycoprotein was referred to the state of ground substance in connective tissue. Therefore serum glycoprotein is expected to increase in scurvy.
It is generally believed that the blood level of calcium does not change, but the clotting time is either not changed or is slightly increased in scurvy. The mechanism of coagulation is still obscure, ionized calcium is considered to be the primary factor involved in the coagulation mechanism. The intimate relationship between calcium and citrate may suggest the change of serum citrate in scurvy.
For this reason, the present author has undertaken a experiment in order to clarify the obscure point involved, and following result was obtained.
The level of serum glycoproteins (expressed as tyrosine) and citric acid was significantly elevated in scurvy of guinea pigs.
