Abstract
In the present study, Disulfiram into the embryonating eggs of white Leghorn, and its toxicity as well as the histological changes produced in the thyroid gland, liver and kidney were investigated. The following results were obtained :
1. Body weight of the embryo demonstrated a tendency to decrease.
2. The amount of allantoic fluid reduced and this reduction was stronger when the concentration of Disulfiram added was lower.
3. The amount of amniotic fluid increased on the 15th day of embryonation, while on the contrary, it decreased on the 18th day of embryonation. This decrease was more conspicuous on the embryos received the Disulfiram injection of lower concentrations.
4. Disulfiram produced the hypertrophy of the thyroid and increased its weight as well.
5. Histological investigation of the thyroid showed characteristic findings such as the degeneration of epithelial cells and enlargement of individual follicles.
6. On histological investigation, necrgsis, cord dissociation of the liver cells and visceral hyperemia were recognized in the liver and moderate retrogressiv degeneration in the kidney.
7. The action of Disulfiram on the chick embryo is probably similar to that of other antithyroid substances.
