Abstract
In the present study, adult female mice received a subcutaneous injection of diethyl-paranitro-phenyl-thiophosphate (Parathion) and histopathological investigations were made on the skeletal muscles (femoral muscles) of their new born sucklings.
Degenerative changes and those of circulatory disturbance observed on the striated musclefibers, namely, granuly, granular degeneration, vacuolar degeneration, colliquative degeneration segmentation, dissociation, swelling, thick and thine nuclear staing, vacuolization etc, were the strongest on the group received 16 mg of Parathion the sucklings of 1 to 7 days and the intensity of those changes diminished following the decrease in the dose administered. The damages caused by the via placental toxicity of Parathion on the skeletal muscles of sucklings were classified into 3 major categories of growth disturbance, degeneration and circulation disturbance. Degenerative changes and those of circulation disturbance were mostly in parallel to the dose of Parathion administered, while the changes of growth disturbance were not necessarily in accordance with the dosage.
