抄録
1. In the present study diethyl-paranitrophenyl-thiophosphate (Parathion) was administered on the female mice in a different doses of 2, 4, 8 and 16 mg/kg twice per week by subcutaneous injetions and biological and pathohistological investigations, were made on the growth of the femur of the sucklings (1, 3, 7, 10, 15 and 20 days old) born during this period of Parathion administration.
2. The growth of femur was inferior on the group received higher concentrations than those received lower concentrations. Groups received lower concentrations showed lesser variation of the individual growth of the femur approaching to the figures of the control group.
3. Changes on the 1st day were characterized by the growth disturbance. Changes on the 3rd day were characterized by the degeneration and the moderation of growth disturbance. While, those on the 7th day were characterized by the moderation of degeneration.
4. On analysing the pathological pictures observed on the femur, aside from the disturbance caused by the toxic effect of Parathion, namely, CHE, the inhibitory influence on the oxydation and reduction system and the hypoxydose of Parathion as well as the direct exposure of embryos in the maternal body are influencing the growth of new horns demonstrating the difference in morphological expressions by chronological factors.
