In many cases, the posterior wall infarction shows no abnormality of diagnostic significance on the electrocardiograms taken by the conventional 12 different methods of leads. A number of special methods have appeared with an intention of improving the diagnostic value for myocardial infarction, but most of them unfortunately are deficient of their scrutinization on normal individuals and accordingly their normal limits have not been confirmed as yet. In the present study, normal limits and availability of those special methods of lead were investigated on 222 normal individuals, 121 of non-infarct and on 23 of posterior wall infarction. 1. With dorsal unipolar lead, Q/R 0.25 can be regarded as the limit of V7 for the diagnosis of infarction, but as Q/R of V8 and V9 show a figure over 0.4-0.5 in the absence of infarction, the value of this method for the diagnosis of infarction is small. 2. With Sdd lead, it was found to have supplementary diagnostic value in the diagnosis of the posterior wall infarction provided that the voltage of QRS (not the difference of low voltage) and the direction P wave (positive) are taken into consideration when Q/R gives a figure over 0.4. 3. D lead of Nehb was recognized to have supplementary diagnostic value, sometimes, when Q/R 0.4 is taken as its limit. 4. VE, VEO and Vo can hay Q/R 0.25 as their limit and especially Vo was found to have the diagnostic value in the diagnosis of posterior wall infarction.
There are a number of reports on the electrocardiogram of myocardial infarction, but the problems on an early stage of infarction require further investigations. 1. On investigating the electrocardiograms of a total of 43 cases of acute myocardial infarction including 13 cases in which relatively frequent follow-up of their cardiograms from the early stage of infarct paroxysms, elevation of ST and repeated appearance of terminal inversion were recognized rather frequently in spite of the absence of recurrent paroxysms, and accordingly, they were considered as normal findings. In some cases, the changes of ST·T appeared repeatedly. 2. On the 20 cases in which the follow-up of their cardiograms from the time as early as within 24 hours after developing infarct paroxysms, the time of the appearance of abnormal Q was investigated. On unipolar precordial lead, the appearance of abnormal Q was recognized within 12 hours on more than half of the cases examined. On aVF lead, however, not a few cases showed slight retardation.
This author happened to come across with a case of horse-shoe kidney which is an extermely rare abnormality with the frequency of appearance only 0.2% of the total autopsy cases. Adhesion at the lower part of the two kidneys was quite solid indicating that this horse-shoe kidney developed in an extremely early stage. The kidney was located low and the hilum which opened frontally and inwardly contained blood vessels and nerves.
1. In the present study diethyl-paranitrophenyl-thiophosphate (Parathion) was administered on the female mice in a different doses of 2, 4, 8 and 16 mg/kg twice per week by subcutaneous injetions and biological and pathohistological investigations, were made on the growth of the femur of the sucklings (1, 3, 7, 10, 15 and 20 days old) born during this period of Parathion administration. 2. The growth of femur was inferior on the group received higher concentrations than those received lower concentrations. Groups received lower concentrations showed lesser variation of the individual growth of the femur approaching to the figures of the control group. 3. Changes on the 1st day were characterized by the growth disturbance. Changes on the 3rd day were characterized by the degeneration and the moderation of growth disturbance. While, those on the 7th day were characterized by the moderation of degeneration. 4. On analysing the pathological pictures observed on the femur, aside from the disturbance caused by the toxic effect of Parathion, namely, CHE, the inhibitory influence on the oxydation and reduction system and the hypoxydose of Parathion as well as the direct exposure of embryos in the maternal body are influencing the growth of new horns demonstrating the difference in morphological expressions by chronological factors.
In the present experiment, diethyl-paranitrophenyl-thiophosphate in a varying dose of 2, 4, 8, 12 and 16 mg/kg was injected subcutaneously into female rats, and after repeating the injections required, they were mated with normal male rats. Pathological investigations were made on the kidney of the new borns thus obtained (sacrificed on the 3rd adn 7th day after birth) and of the maternal rats, and at the same time, the relationship of the effect of maternal intoxication to the placental cord was investigated. In summarizing the renal findings of acute groups, they can be said as the acute diffusive glomerulonephritis accompanying the alternative “ Veränderung ” of the tubular epithelium. As for the changes produced in the glomeruli, moreover, the toxic effect is considered to exert direct primary damages on the endothelial cells of the loop. Consolidative changes observed on chronic groups are the final picture of acute glomerulonephritis and interstitial hydroma is considered to have played the most important role in the production of these fibrotic changes. Renal disorders of the suckling rats were proved to consist of inflammatory, retrogressiv and growth disturbing changes. The fact that the renal changes of the suckling rats were always milder than those of the mother rats is construed as the expression of the inhibitory influence of the placental cord against the transmission of toxic substances.
1. In the present experiment, Parathion (diethyl-paranitrophenyl-thiophosphate) was administered subcutaneously in a varying dose of 2, 4, 8, 12 and 16 mg/kg twice per . week on adult rats and histopathological investigations were made on the liver of each animal. 2. Vacuolar degeneration and various other retrogressive and tissue traumatic changes of hepatic cells observed in the present experiment are considered as the lesions formed by the tissue intoxication due to the hypoxydosis caused by the administration Parathion. 3. Changes of hepatic cells which advance from the tissue traumatic changes, namely, colliquative changes to the circumscribed necrosis are considered to be non-reversible. 4. Glisson's sheath and the interlobular connective tissues were seen to have undergone hydromatous expansion clearly demonstrating each lobular construction and the oppression, atrophy, destruction etc of hepatic cells were recognized on the part where lobules contact each other. In view of the changes listed above, healing processes are considered to follow fibrous consolidation together with hydromatous consolidation. 5. Colliquative degeneration is considered as a prodromal phenomenon of localized necrosis. At the stage of colliquative degeneration, however, it is difficult to demonstrate the movement of the distribution of fat morphologically. Fat is considered to appear when there occur considerable changes in the construction of hepatic tissues by the advancement of colliquative changes.
It was in earlier papers shown that anemia producing substance of the human serum was merely found out in the patients of hypoplastic anemia, nephritis and cancer. In this paper, it was described that this substance was also demonstrated in the serum of normal healthy persons. The numbers of erythrocytes and hemoglobin were markedly decreased after repeated injection of normal serum with ascorbic acid showed a tendency to prevent the decrease of erythrocytes and hemoglobin after injection in the rabbits. The numbers of reticulocytes, leucocytes and platelets were unchanged before and after injection of normal serum. Repeated injection of serum to rabbits produced hypoplastic bone marrow, but injection of ascorbic acid treated serum to rabbits were not caused hypoplastic bone marrow. And the correlation between anemia producing substance and globulin substances obtained from 10-fold redistilled water diluted plasma by acetic acid precipitation at pH 5.9-6.1.
Methods of anesthesia to be employed during operation have become nearly complete, but unfortunately systematic treatment of the postoperative pains of abdominal surgery has not yet been fully developed. In order to establish some counter measures, the nature of postoperative pains was investigated on a total of 56 cases of gastrectomy. As the result of this investigation, the postoperative pains were found to be classified into two groups of those appearing early and those in retard, and the proper treatment of early pains could eliminate the appearance of those in retard. For this purpose, however, topical and symptomatic treatments were not sufficient, and it became necessary to introduce some systemic method of anesthesia comparable to the one employed during operation. Intravenous instillation of pentobarbital natrium (P. B. N.) previously reported by one of the author's colleagues Umezu was confirmed to be quite satisfactory for the present purpose. With an intention of improving his method of anesthesia, this author employed the intramuscular injections of P. B. N. supplemented by Opystan or Chlorpromazine. Alternate injections of P.B.N. intramuscularly in a dose of 0.1 g and Opystan subcutaneously in a dose of 35 mg with intervals of 3 hours were found to give the best results (effective rate of 98%) . Accordingly, the alternate injections of P. B. N, and Opystan have become a routine procedure for the removal of postoperative pains in the author's clinic. This method, however, gave rise to the side reactions of excitement in approximately 8% of the patients received the treatment. Inhibition of this side reaction is the problem for the future studies.
Corrosion preparations of the hepatic vessels were made from 20 cases of human embryos and the transformation of viteline and umbilical veins in the region of the liver was investigated on 10 preparations in which the infusion was complete. Result of this investigation revealed that first V.viteline is formd in the liver, and then, V.umbilicalis is combined to it forming V. advehens which changes into V.revehens after passing through the capillary plexus and joins to V. cava inferior. On rare occasions, however, V, revehens which enters directly into V. cava inferior is located beneath the right side V. suprarenalis.