Abstract
In the present study, a mammary tumour spontaneously developed in a mouse of dbr strain was transplanted on the male mice of the same strain and Enarmon and Parotin injections were made before and after transplantation of the tumour under varying conditions for the histopathological observation of their influence on the development of the tumour itself as well as on the surrounding tissues, especially, on the skin covering it with special reference on the hydropic lesions.
1. Atrophy and thinning of the epidermis of the skin covering tumour were found to parallel the size of tumour when it was spherical.
2. Histopathological changes due to the transplantation of tumour observed on the mice of Enarmon administration were comparable to those of the control group being much severer than those observed on the mice of Parotin administration with more marked tubular and cystomatoid formation. These findings are in agreement with the theory to say that, in the study of mammary tumour, the organs which have undergone higher histological differentiation show quicker growth rate.
3. Throughout these two experimental groups, all cases showed the presence of marked hydropsia in the subcutaneous tissue and the infiltrative proliferation of tumour cells into it with only 1 exception necessitating the important role played by hydropsia in the expansion of the tumourous tissue.
