抄録
Studies were made on the relationship between cardiac function and thiamine content in blood of rabbit following administration of large amounts of thiamine. Further, the principal cause of the acute toxic death of animals after injecting thiamine was investigated. The concentration of thiamine in blood at the convulsion period was 41-18 mg/dl, but it decreased extremely after 30 minutes (40 % of the convulsive concentrations) . No remarkable change was recognized in cardiac function at 30 mg/dl of thiamine. By the toxic dose of thiamine (90 mg/kg) convulsion and respiratory failure occured, while heart beat continued 10 minutes with slight lowering blood pressure.
As there was no direct relationship between cardiac function and thiamine contents in blood it is assumed that the principal cause of the acute toxic death of animals with thiamine is led by the respiratory paralysis.
