抄録
Large amounts of thiamine (300-700 mg/kg) was injected subcutaneously to fowl for consecutive 30 days. The following results were obtained.
1. Body weight decreased slightly.
2. The 24 hours urines after injection were collected and determined the contents of thiamine in these urines. The percentage of thiamine excreted to the amounts administered was less than 50%. The urinary excretion of 2-methyl-4-amino-5-hydroxymethylpyrimidine, component of thiamine and its oxidative product, 2-methyl-4-aminopyrimidyl-5-carboxylic acid were not observed.
3. Moderate degenerative histopathological change was detected in the liver and lung, -whereas no remarkable change in gallbladder, pancreas and spleen.
4. No appreciable effect was observed on kidney-anserinase activity of the fowl.
