滲出機転亢進と脾の態度について

抄録

In order to study the hypoxic influence of hemolysis, 0.5 ml/kg of phenylhydrazine (P.h) was injected subcutaneously into rabbits every three days at a concentration of 2%, 4% and 8%, respectively. The rabbits were then sacrificed on a specified day, and the spleens were examined histologically.
1. Acute group:
The spleen showed primarily edema and hemorrhage due to congestion, with scattered foci of necrosis and mild extramedullary hematopoiesis. The deposition of hemosiderin was comparatively marked, and it was noted that there was a slight tendency towards increased pigment deposition with an increase in dosage of P.h.
2. Chronic group:
The splenic parenchyma contained areas of focal necrosis and fibrosis, accompanied by diffuse fibrous proliferation and disruption of the splenic architecture. The hemosiderion deposition was further marked. The arterioles showed sclerotic changes, and foci of extramedullary hematopoiesis were noted.
3. While various hematologic changes result from the red blood cell destruction in the spleen and the hemolytic anemia induced by P.h administration, the morphologic changes of edema, necrosis, and fibrosis are caused by a permeability disturbance of the sinusoidal wall and small blood vessels of the spleen due to the hypoxic influence.
It is considered that the degree of morphologic change will vary directly with an increase in P.h dose.