Vitamin B₆拮抗体による痙攣とその抑制効果について

抄録

Seizure symptoms were observed by giving vitamin B₆ antagonists, each of them haying different antagonistic mechanism, to mouse. Then, the influence of the administrationn of B₆ and the related substances upon the seizure, which appears by the administration of B₆ antagonists, and the relationship between the seizure and 5-hydroxytryptamine (5-HT) in the brain were studied.
1) Running fit was observed, when 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP), isonicotinic acid hydrazid and DL-penicillamine were subcutaneously and intraventricularly injected. The latent period was the same in both administration methods and the intraventricular dose of onsetting the fit was 1/7 to 1/80 of the subcutaneous dose.
2. With deoxypyridoxine, cycloserine, and p-aminosalicylic acid, different symptom was observed between the two administration methods. Running fit was not observed by these B₆ antagonists.
3. There seems to be no relationship among B₆ antagonistic mechanism, seizure symptom and seizure onset mechanism.
4. Pyridoxine (PIN) and amino-oxyacetic acid seem to show some protective effects against B₆ antagonists which cause running fit.
5. The protective effect of PIN against OMP seizure was shown with 1/10 of intraperitoneal dose, when injected ventricularly.
6. By intraventricular administration of γ-aminobutyric acid and γ-amino-β-hydroxybutyric acid, onset of OMP seizure was not prevented.
7. B₆ derivatives showed only the similar effect to PIN against OMP seizure.
8. Among B₆ antagonists that cause running fit, only with OMP, a remarkable decrease of 5-HT content in the brain was observed. This decrease was also observed, when seizure was prevented by the administration of anticonvulsants.