Ethyladrianol, Butylsympatol, Metaproterenolの2～3動物の非妊および妊娠子宮に対する作用
1974 年 34 巻 3 号 p. 225-233
詳細
1974 年 34 巻 3 号 p. 225-233
Effects of ethyladrianol, butylsympatol and metaproterenol on isolated uterus in pregnant and nonpregnant rabbit, rat, guinea-pig and mouse were investigated.
The results obtained were as follows :
1) By the administration of ethyladrianol at all doses tested, uterine motility in nonpregnant guinea-pig or rabbit was stimulated. On the other hand, ethyladrianol at all doses caused inhibition of uterine motility and contractile activity in uterine smooth muscle in pregnant rabbit and guinea-pig, except at lower dose uterine motility in pregnant rabbit was stimulated. It caused inhibition of uterine motility in pregnant and nonpregnant rat and mouse, regardless of its doses used.
2) Butylsympatol and metaproterenol caused inhibition of uterine motility in pregnant and nonpregnant rabbit, mouse and rat regardless of its doses used. They caused stimulation of uterine motility in nonpregnant guinea-pig at all dose tested, except higher doses tested showed marked inhibition of uterine motility in pregnant guinea-pig. Therefore, adrenergic β-receptor stimulanting agents generally showed inhibitory effects on uterine smooth muscle.
3) The sensitivity of three adrenaline derivatives tested to pregnant uterine motility is 10 times as higher than that to nonpregnant case.
