昭和医学会雑誌
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
34 巻, 3 号
選択された号の論文の11件中1~11を表示しています
  • 堀 豪一
    1974 年 34 巻 3 号 p. 213-223
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The author attempted to grasp the hemodynamic phase of lower extremities in sixtyone patients with chronic obstructive arterial disease (TAO forty-eight, ASO thirteen) including twenty-nine control subjects without ischemic symptom, by means of directly intramuscular injection of 133 Xenon (30-100 μci) and recorded it's clearance curve.
    The following six parameties were measured from the clearance curved and the results. were discussed with clinical symptoms, plethysmograms and arteriograms.
    (1) Rest Muscle Blood Flow (MBFR)
    (2) Muscle Blood Flow during exerese (MBFE)
    (3) Postexerise Muscle Blood Flow (MBFH)
    (4) Duration time from the cessation of exercise to postexercise hyperemia (T-time)
    (5) Index indicating hyperemia one minute after the cessation of exercise (R-indx)
    (6) The angle between the horizontal line and the tangent line which was drawn at the clearance curve one and half minute after the beginning of exercise curve was stabilized (γ Angle) .
    The author also evaluated the clinical utility of RI-Scintigram and acid-base balance in occulusive arterial disease.
    The peripheral micro circulation insufficiency is thought to be result in metabolic acidosis and in PH decrease in peripheral capillary blood.
    PH measurement is also instrumental in the study of morbidity of ischemic extrimity of the chronic obstructive arterial disease.
  • 荒原 唯守
    1974 年 34 巻 3 号 p. 225-233
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Effects of ethyladrianol, butylsympatol and metaproterenol on isolated uterus in pregnant and nonpregnant rabbit, rat, guinea-pig and mouse were investigated.
    The results obtained were as follows :
    1) By the administration of ethyladrianol at all doses tested, uterine motility in nonpregnant guinea-pig or rabbit was stimulated. On the other hand, ethyladrianol at all doses caused inhibition of uterine motility and contractile activity in uterine smooth muscle in pregnant rabbit and guinea-pig, except at lower dose uterine motility in pregnant rabbit was stimulated. It caused inhibition of uterine motility in pregnant and nonpregnant rat and mouse, regardless of its doses used.
    2) Butylsympatol and metaproterenol caused inhibition of uterine motility in pregnant and nonpregnant rabbit, mouse and rat regardless of its doses used. They caused stimulation of uterine motility in nonpregnant guinea-pig at all dose tested, except higher doses tested showed marked inhibition of uterine motility in pregnant guinea-pig. Therefore, adrenergic β-receptor stimulanting agents generally showed inhibitory effects on uterine smooth muscle.
    3) The sensitivity of three adrenaline derivatives tested to pregnant uterine motility is 10 times as higher than that to nonpregnant case.
  • ―特に小児の全血について―
    国保 喜寛
    1974 年 34 巻 3 号 p. 235-248
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Many determination methods of antibiotics concentration in the body fluid are available, but there are a few simple micromethod for determination, especially in the cases of premature, newborn and young children.
    The auther diviced a vertical diffusion method using agar medium in tube. The material isnstilled in gauze was put on the medium and the procedure was carried out according to Torii-Kawakami method. The materials were phosphate buffer, serum and difibrirated blood that contain antibiotics.
    In the examination in vitro, the result with Amino-benzyl Penicillin (Ab-Pc), Cepha-loridin (CER), Acetyl-Spiraymycin (Ac-SPM), Lincomycin (LCM), Tetracyclin (TC) and Chloramphenicol (CPL) corresponded completely that with Torii-Kawakami method. The effect of serum and blood cell on the drugs was different from each drugs. Especially, inhibitory zone by putting blood cells on the medium became shorter than that by putting serum. The standard curve of the former was narrowed than that of latter.
    In clinical medication with Ab-PC, CER, Ac-SPM and LCM, the result was corresponded with Torii-Kawakami method.
    The inhibitory zone using whole blood was shorter like the examination in vitro. The active concentration of whole blood which was determined with standard curve using human defibrirated blood was hardly different from that using serum. Because of difficulty of getting human defibriated blood, defibriated blood of horse was used. In the examination with Ab-PC, CER and LCM, no defference between the inhibitory zone by defibrirated blood of human and horse was found.
    In conclusin, auther's micromethod of determination was seemed to be usef ull as a laboratory examination for antibiotics concentration in the cases of premature, newborn and young children, because of little difficulty of technique and the small amount of the meterial.
  • 加藤 厚志
    1974 年 34 巻 3 号 p. 249-259
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Guinea pigs were divided into feed groups, and fed diets different in far content and deficient in vitamin C. After appearance of deficiency symptoms, they were given vitamin C, and total vitamin C in blood and organs (liver, spleen and adrenal) as well as lipid fractions (total lipid, total cholesterol, cholesterolester, neutral fat, free fatty acid, phospholipid and lipoperoxide) were determined every ten days.
    The results obtained are as follows :
    1) The symptom of vitamin C deficiency was faster in appearance and later in disappearance as the fat content of diet was increased.
    2) Total vitamin C in blood and organs was not clearly correlated with the fat content of diet.
    3) When the diet was deficient in vitamin C, the adrenal and spleen increased in weight, and vitamin C decreased in the adrenal among others.
    4) Total lipid and each fraction of lipid increased in serum every day in case the diet was deficient in vitamin C and decreased after administration of it. Total cholesterol, free fatty acid, and lipoperoxide showed remarkable changes irrespective of the dietal level of fat, though the changes were especially striking in the rats on the medium-fat diet.
    5) The increase of total cholesterol was greater than that of total lipid, resulting in a relative decrease of cholesterolester.
    6) The results mentioned above suggest that vitamin C promotes lipid metabolism and prevents accumulation of lipid in the body.
  • 菅野 明
    1974 年 34 巻 3 号 p. 261-270
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Healthy young Wistar rats, weighing 80 to 100 g, were divided into two pressure groups : reduced pressure group (for rearing in a tank under 1/2 atmospheric pressure) and normal pressure group (for rearing under atmospheric pressure) . They were subdivided into three feed groups, and fed high-medium, and low-protein diets deficient in vitamin B2 to investigate the metabolism of vitamin B2 and protein under hypoxic reduced pressure. Symptoms of vitamin B2 deficiency in these rats was examined, and total vitamin B2 in blood, changes of body weight, tatal protein and protein fractions in serum, and total lipid and lipid fractions in serum were determined. Then vitamin B2 was administered to these rats to investigate the effect on the improvement of their conditions. The results obtained were as follows :
    1) When vitamin B2 was deficient, such symptoms as bad looks of hair, loss of hair, inactivity and weight loss were more remarkable, and disturbance of growth was greater in the rats of the reduced pressure group than in those of the normal pressure group. The appearance of these symptoms was markedly earlier especially in the low-protein group than in the medium-and high-protein groups.
    2) Total vitamin in blood was observed to decrease from the beginning of the experiment, especially in the reduced pressure and low-protein group.
    3) A slight decrease in total protein and albumin, and an increase in α2-globulin and γ-globulin were observed in blood. These symptoms were comparatively greater in the reduced pressure and low-protein group.
    4) The contents of total lipid and lipid fraction in serum increased strikingly. They were higher in the reduced pressure group than in the corresponding control, and comparatively greater in the low-protein group.
    5) In the recovery experiment, improvement of vitamin B2 deficient conditions as well as weight gain was observed after administration of the vitamin. Tatal protein and albumin remained unchanged or increased slightly, α2-globulin and γ-globulin tended decrease a little, and total lipid and lipid fractions showed a decrease in serum.
  • 堀坂 和敬, 中山 貞男, 岡崎 雅子, 宮下 幸夫, 坂木 洋, 宮坂 宗男, 森本 祐二郎
    1974 年 34 巻 3 号 p. 271-283
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    A study was made of the general pharmacological activities of L-carnosine by using synthetic L-carnosine ; and the following were found :
    1. The intraperitoneal LD50 of L-carnosine to mice was 9, 087 mg/kg. The observation of the general activities of mice and rabbits also proved L-carnosine to be a compound with very low acute toxicity.
    2. L-carnosine, when administered to animals, exerted no particular effects on the CNS of the animals. The compound further proved not antagonistic to the convulsions induced with strychnine and pentetrazol.
    3. L-carnosine was administered in conjunction with barbiturate, to examine its effect on the sleep induced with the latter, and it was revealed that the intraperitoneal doses of not lower than 150 mg/kg significantly prolonged the sleeping time.
    4. L-carnosine failed to vary the body temperature in normothermic and hyperthermic animals. The compound further proved inert on blood coagulation, biliary secretion, pen-pheral blood vessels and transport movements of the small intestine.
    5. The intravenous doses of not less than 50 mg/kg of L-carnosine caused transient hypotention in rats.
    6. L-carnosine, in 0.1 to 10.0 % concentrations, exerted a surface anesthetizing effect on the rabbit cornea.
    7. The intraperitoneal doses of not less than 100 mg/kg of L-carnosine were inhibitory to urination in mice.
  • 堀坂 和敬, 中山 貞男, 森本 祐二郎, 山川 晃弘
    1974 年 34 巻 3 号 p. 285-299
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    A study was made of the analgesic and anti-inflammatory effects of L-carnosine as well as its wound healing effect by use of synthetic L-carnosine : and the following were found:
    1. L-carnosine exerted an inhibitory effect on enhanced vascular permeability induced by the intraperitoneal infusion of acetic acid or bradykinin. The compound proved only 1/5 to 1/20 as inhibitory to enhanced vascular permeability with bradykinin as aminopyrine.
    2. L-carnosine, when tested for anti-edematous action by carrageenin-, bradykinin-and dextran-edema methods, proved to exert an effective anti-edematous action.
    3. L-carnosine, when tested by the writhing method and Randall and Selitto's method, proved itself to be slightly analgesic. Its analgesic action was about 1/20 as potent as that of aminopyrine.
    4. The effect of L-carnosine on granulation was tested by both the formalin-filter paper pellet method and the agar implantation method. The intraperitoneal doses of not less than 32 mg/kg of L-carnosine promoted granulation. This granulation promotive action could not be achieved by the administration of the component amino acids of L-carnosine, namely, L-histidine and β-alanine. Further, the oral doses of not higher than 120 mg/kg of L-carnosine failed to exert an apparent granulation promotive effect.
    5. 64 mg/kg of L-carnosine, when subcutaneously infused into rats, apparently improved the wound diminishing rate in the round skin defective wounds (2 cm in diameter) provided in the dorsal region of the animals. Histologic examination further proved that L-carnosine exerted a positive, promotive effect on the wound healing process.
  • 第31報脳中のMAOの複数性について
    黒澤 正憲
    1974 年 34 巻 3 号 p. 301-306
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Effects of oxygen concetration on MAO activity in beef brain mitochondria with various amines as substrates were investigated. The MAO activity was assayed by measuring oxygen consumption by the Warburg manometric method at 38°C. It was found that the changes in oxygen concentration caused significant effects in MAO activity and the affinity of enzyme to oxygen with tyramine as substrate was differ from that of enzyme with serotonin. In addition, the following results were obtained.
    94
    1) The substrate specificities of beef brain mitochondrial MAO in 20% and 100% oxygen concentration were investigated. In 20% oxygen concentration, the MAO activity with dopamine as substrate was found to be greatest and was followed with tyramine, tryptamine, serotonin and β-phenylethylamine. On the other hand, in 100% oxygen concentration, the greatest MAO activity was found with tyramine as substrate, and was followed with dopamine, tryptamine, β-phenylethylamine and serotonin. All activities, mentioned above, proceeded lineally within the initial 20 minutes.
    The changes in MAO activity with changes in oxygen concentration between 5 to 100% were investigated. The MAO activites with tyramine as substrate was decreased by the decrease in oxygen concentration from 100 to 5%. However, the MAO activites with benzylamine and serotonin as substrate were changed markedly only when the oxygen concentration was below 20%, while no chang was observed when it was above 20%.
    3) The Km values against oxygen with tyramine, tryptamine and dopamine as substrate were 133 pM and that with serotonin as substrate were 50 pM.
    4) The inhibition of MAO by catronwith tyramine as substrate was noncompetitive against oxygen and with serotonin as substrate was competitive.
  • 渡辺 静一, 大栗 茂芳, 山下 茂樹, 川瀬 定夫, 岡野 武史, 森川 昭洋, 相澤 哲郎, 津田 紘輔, 中津 正雄
    1974 年 34 巻 3 号 p. 307-313
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    The patient was a 69 year -old housewife who was admitted to our hospital with chief complaints of headache and stupor.
    The patient has been known to have high blood pressur since 67 years old.
    On the ninth hospital day the both eyes were deviaced upward and its movements were limited downward and to the left, the tongue deviated toward the left side on protrusion.
    Examination of the nervous system disclosed the paralysis of oculomotor nerve and hypoglossal narve. The tendon reflexes were symmetrically diminisched in the legs, and a bilateral Babinski sign was elicited.
    During the two months of this hospitalization the patient remained stupor or comatos. She died and was diagnosed subarachnoid cerebroventricular hemorrhage at autopsy, and it was definded that a ruptured aneurysm of the right posterior communicating artery has been presented.
  • 田口 進, 坂本 言方, 須沢 忍, 草ヶ谷 雅志, 桜井 大和, 池田 左千雄, 小貫 誠, 八田 善夫, 清水 盈行
    1974 年 34 巻 3 号 p. 315-324
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
    Many cases of pancreatolithiasis as a relatively terminal state of chronic pancreatitis have been reported in Europe and America, but in recent years, an increasing number of cases of this disease have been reported in Japan, too, as the pancreatic function test has been positively performed. We have encountered four cases of pancreatolithiasis. and the findings are presented hereunder.
    Alcohol is one of the major causes of pancreatolithiasis. It is responsible in about 20% of the cases of this disease in Europe and America. Three cases (75%) out of the four encountered by us were reported to have been heavy drinkers for many years. A dietary factor (namely, low-protein, high-fat diet), too, appeared to be involved in them.
    Diabetes mellitus is frequently encountered as a complication, and it was found in all of the ; four cases. It is characteristic of pancreatic diabetes that the disease is refractory, and not a few cases are in need of insuline. Two of the four cases were not well controlled. In the aspect of pancreatic function, the three factors of P-S test are low in many cases, and in the four cases, the max CO2 and amylase output were markedly lower than those in cases of non-calcifying chronic pancreatitis.
    Pancreatic scintigram show a decreased uptake of isotope by the pancreas, namely, an obscure shadow. It appeared in the four cases that these test results were relatively well consistent with the intensity of histologic changes in the pancreas.
  • 中川 克也, 安原 一, 庄 貞行, 杉山 喜彦, 風間 和男, 田代 浩二, 生田目 公夫, 山田 満昭, 猪口 清一郎, 岩本 壮太郎, ...
    1974 年 34 巻 3 号 p. 325-328
    発行日: 1974/06/28
    公開日: 2010/09/09
    ジャーナル フリー
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