Abstract
Rabbits were infused subcutaneously with hydroxylamine hydrochloride (H.A.) to check variations in blood picture that followed, and as a result, it was proved to be a chemical compound which would cause hemolytic anemia.
1) Hemoglobin levels in both the group treated with 15 mg./kg. of H.A. and the group treated with 30 mg./kg. fell to 6.8 g./dl. two to three days after infusion of the compound, being as low as 4.0 g./dl. in some animals.
2) Infusion of both 15 mg./kg. and 30 mg./kg, of this compound was followed by abrupt elevation of its level, and it was as high as 94% in the group treated with the latter dose on the second day. However, it remained about 85% on the average in the subsequent stages of experiments.
3) Methemoglobin was detected at levels of 0.26 to 0.51 g./dl in the experimental animals 240 days after infusion of 15 mg./kg, of H.A.
