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Volume 34 (1974)
- Issue 6 Pages 539-
- Issue 5 Pages 439-
- Issue 4 Pages 329-
- Issue 3 Pages 213-
- Issue 2 Pages 115-
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Volume 34, Issue 5
Displaying 1-11 of 11 articles from this issue
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Sekiya Kojima1974 Volume 34 Issue 5 Pages 439-453
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSUsing 210 autopsy cases of newborn infants, the degree of development of gastric muscle layer was studied stepwise pathomorphologically. Furthemore, using 6 cases of gastric rupture in newborn infants, the cause of rupture was studied and the following conclusions were obtained.
1. The gastric muscle layer differentiated and develops in proportion to the week of fetal life. The circular muscle layer reaches the standard growth level at the 37 th week of fetal life, while the longitudinal muscle layer develops similary in the 29 th week.
2. As to the site, the best development was achived in the pylorus, followed by the corpus, and fundus, with no difference between the greater and lesser curvature
3. In the gastric muscle layer of the newborn infants, the site of physiological lack of circular muscle layer was demonstrated. The presence of thin portion was also confirmed.
4. As to the correlation of 3 factors, longitudinal muscles, oblique muscles and thinning on this fissure, 8 types of fissures could be distinguished.
5. Among the 8 types, the fissure with lack of longitudinal and oblique muscle with thinning appears to be the most dangerous portion in the newborn stomach.
6. Such a portion occupies 18.6% of the ruptured fissure, 20 times as high as than in the non-ruptured cases.
These results would indicate that such a dangerous portion is prone to rupture by the action of some factors even if such a defect is not the direct cause of the rupture.View full abstractDownload PDF (10070K) -
Makiko Asaga1974 Volume 34 Issue 5 Pages 455-465
Published: October 28, 1974
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESS1. Elevated blood fibrinolytic activity was observed immediately after tonsilectomy, especially in those cases that had excessive hemorrhage or prolonged operation time, tonsil massage, and X-ray, while blood fibrinolytic activity in acute tonsillitis was retained in the normal level regardless of the clinical manifestations and courses
2. Extraction method of fibrinolytic substances from tonsil tissue was improved with use of French Press method and the time and procedures for the extraction were shortened and simplified. Amount of plasminogen activator extracted from tonsil of chronic hypertrophy was not markedly different from that of chronic tonsillitis.
3. Intracellular localization of fibrinolytic substances of tonsilla palatina was investigated by cell fractionation method. Plasminogen activator was present prominently in the soluble, mitochondrial, and lysosomal fractions. Plasmin-like substance was found in the soluble and microsomal fractions. Anti-plasmin substances existed only in the large granule fraction
4. Plasminogen activator extracted from tonsil was markedly inhibited by anti-plasmin agents such as t-AMCHA (Trnsamine) and ε-ACA (Ipsilon)
5. Uptake of 3H-labeled t-AMCHA by tonsil slices was rappid and labeled t-AMCHA was found much in the soluble and mitochondrial fractions.View full abstractDownload PDF (1167K) -
THE EIRST PART. ON THE CHANGES OF THE BLOOD DUE TO HYDROXYLAMINE HYDROCHLORIDEShiro Tamura1974 Volume 34 Issue 5 Pages 467-473
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSRabbits were infused subcutaneously with hydroxylamine hydrochloride (H.A.) to check variations in blood picture that followed, and as a result, it was proved to be a chemical compound which would cause hemolytic anemia.
1) Hemoglobin levels in both the group treated with 15 mg./kg. of H.A. and the group treated with 30 mg./kg. fell to 6.8 g./dl. two to three days after infusion of the compound, being as low as 4.0 g./dl. in some animals.
2) Infusion of both 15 mg./kg. and 30 mg./kg, of this compound was followed by abrupt elevation of its level, and it was as high as 94% in the group treated with the latter dose on the second day. However, it remained about 85% on the average in the subsequent stages of experiments.
3) Methemoglobin was detected at levels of 0.26 to 0.51 g./dl in the experimental animals 240 days after infusion of 15 mg./kg, of H.A.View full abstractDownload PDF (697K) -
Akiyo Kinohira1974 Volume 34 Issue 5 Pages 475-488
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSNach Untersuchungen fiber die Beeinflussung von Nornicotin and semen verwandten Verbindungen auf die Entwicklung des befruchteten Huhnereies kam man zu folgenden Ergebnissen.
Die Bebrutung erfolgte unter ständig kontrollierten konstanten Temperatur-und Luftfeuchte-bedingungen. Die in wässriger Lösung bereiteten Prüfsubstanzen wurden in den Luf traum der Hühnereier bei Nornicotin and in das Eierklar bei semen verwandten Verbindungen infundiert.
1) Fur die Applikation von Nornicotin vor der Bebrutung zeigte sick etwas Ähnliches wie bei der Einspritzung in das Eierklar and den Eidotter.
2) Die Letalität der Hühnerembryonen lag bei Nornicotin niedriger im Vergleich zu Nicotin, aber bei 4-6 tägiger Applikation nach der Bebrütung in einem hohen Prozentsatz. Zum grösseren Teil waxen sie innerhalb 2 Tagen abgestorben.
3) Die Allgemeinentwicklung wurde bei 4 tägiger Applikation nach der Bebrütung stark gehemmt.
4) Hydrops konnte durch das zu verschiedenen Zeitpunkten der Bebrutung applizierte Nornicotin entstehen.
5) Unter den Entwicklungsanomalien wurden Schiefhals, Deformierung der Wirbelsäule and Wachstumsstörung des Schnabels bei 2-6 tägiger Applikation von Nornicotin in einem hohen Prozentsatz nachgewiesen.
6) Durch die histologischen Untersuchungen wurden pathologische Veränderungen der Leber, des Herzens and des Oberschenkelknochens im verschiedenen Ausmass nachgewiesen.
7) Als die verwandten Veranndungen von Nornicotin wurden Cotinin, Desmethylcotinin, 6-Hydroxymyosmin, Pseudoxynicotin, 3-Acetylpyridin Pyridin and Pyrrolidin zur Untersuchung herangezogen.
Vor allem wurde bei der Applikation von Pseudoxynicotion die Allgemeinentwicklung stark gehemmt and wurden verschiedene Entwicklungsanomalien nachgewiesen. Im allgemeinen wurde Erzeugung von Hydrops bei der Öffnung des Pyrrolidinrings im Vergleic zu Nornicotin in dem Masse nicht gezeigt. Besonders erwahnenswert ist der Befund, lass das Verbindungsprodukt von Pyridin and Pyrrolidin, welche an rich zu keinem eindeutigen Ergebnis fuhrten, stark teratogene Eigenschaften haben kann.View full abstractDownload PDF (12618K) -
Tadashi Kimino1974 Volume 34 Issue 5 Pages 489-500
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSFor the determination of galactose, the enzymatic method and the so-called our microbioassay method have been compared in various points.
Galactose oxidase method is a kind of colour reaction, using galactose oxidase, substrate, peroxidase, chromogen and spectrophotometer. Microbioassay method is the ordinary cup-plate method, using highly galactose-sensitive mutants of enteric bacteria as the test organisms in order to demonstrate the inhibition zone.
In the oxidase method, the combined galactose is oxidized by the enzyme as well as free galactose with few exceptions. In microbioassay method, free galactose is most active against the mutants. Therefore, if the galactosides are not reactive to the mutants employed, they must previously be hydrolyzed by dilute mineral acids to release the free galactose. Event when the galactosidase-positive mutants are used as the test organisms, the appearance of inhibition zone is greatly interfered in the case of galactosides.
In the enzymatic method, the end point of the titre is 25 γ/2ml ; and 200-500 γ/2ml when deproteinizing or desalting is necessary in the biological samples. In the microbioassay, the end point is 1.25 γ/0.1 ml, and usually there is no need to carry out deproteinizing or desalting. The range of reliable determination for galactose is 25-100 γ/2ml in the enzymatic method, and 1-10 γ/0.1 ml in the microbioassay method. The length of diameter of inhibition zone by galactose is not influenced by the presence of other hexoses, unless their amounts exceed that of galactose by 7-8 times.
The time required for the procedures is 3-4 hours, or some hours more if deproteinizing or desalting is necessary, in the enzymatic method, and about 8 hours in the microbioassay when stocked seed-layer plates are utilized.
In the galactose oxidase method, the result should be read within 6 hours. On the contrary, the inhibition zone remains unchanged for a few days in the microbioassay.
In the oxidase method, lactulose is reactive, but lactose is not. In the microbioassay, lactulose is not reactive, but lactose is reactive when the mutant producing -galactosidase is employed as the test organism.View full abstractDownload PDF (4594K) -
Yujiro Morimoto1974 Volume 34 Issue 5 Pages 501-510
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSStudies were performed to investigate the blood pressure-lowering effect of homotaurine-choline (HT-ch) and its influence on experimentally induced hyperlipidemia. HT-ch is a molecular compound of 3-aminopropanesulfonic acid (homotaurine) and choline chloride. The results were as follows:
1) HT-ch produced a hypotensive effect in rats, the degree of action being approximately intermediate between homotaurine and choline.
2) The data obtained indicate a possible involvement of the central nervous system in the hypotensive action of HT-ch, as is the case of homotaurine. Besides, it was also suggested that this compound of higher order being a derivative of choline might affect on effectors of cholinergic postganglionic fibers.
3) Young rats with low body weights which had been maintained on a high fat diet containing 2 per cent of cholesterol and 1 per cent of cholic, acid for 3 days developed a marked hypercholesterolemia. Elevation of other serum lipids was also prominent in these animals.
4) Administration of taurine or 1-amino-2-hydroxypropanesulf onic acid brought about lowering of serum lipid levels in rats with hyperlipidemia receiving high doses of these compounds. In contrast, a significant decrease in serum lipid concentration occurred following administration of homotaurine even in low doses, and the antihyperlipidemic effect was moreover marked in rats receiving HT-ch.
5) Normal rats given homotaurine exhibited a significant fall of serum lipid level whereas administration of HT-ch failed to produce any significant change in this respect.View full abstractDownload PDF (3656K) -
Kazumasa Yasumoto, Hiroshi Yogi, Kimio Honda, Koichiro Oshikawa, Shiro ...1974 Volume 34 Issue 5 Pages 511-515
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSA 32-year-old femal had been suffering from recurrent sever bronchial asthma attack, so we studied her condition by lung function test and controlled attack by inhalation therapy with IPPB before operation.
But during dilation and curettage under low spinal anesthesia sever bronchospasm occured and progressed to cardiac arrest.
The usual treatment couldn't cure this moribund attack, but intrabronchial lavage with bronch-dilator agent and inhalation therapy using IPPV were effective.View full abstractDownload PDF (3121K) -
Kazuo Imamura, Takayuki Suga, Tsuneo Kondo, Tsuneo Matsui, Hideki Yosh ...1974 Volume 34 Issue 5 Pages 517-521
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe primary hyperparathyroidism presents various clinical symptoms on which increasing numbers of reports have been sent from different institutions. The case which we observed also showed considerable changes in the bones and urolithiasis were found.
This female patient, aged 27, complained of left flank pain and gross hematuria in December, 1969. She had had the fracture of the right femoral bone in May, 1969. Due to the chemical examination the serum calcium levels were 13.4-14.8 mEq/L ; the serum phosphate levels were 1.3-2.8 mg/100 ml ; the 24 hour-urinary excretion of calcium was 173-569 mg; the 24 hour-urinary excretion of phosphate was 21-702 mg ; %TRP was 50-70 percent which was low. We performed a surgical operation removing the parathyroid tumor in February, 1970. The weight of tumor was 2.6 grams and the pathological diagnosis was parathyroid adenoma. This patient is progressing favorably.View full abstractDownload PDF (5111K) -
Osamu Yamaguchi, Masao Nakatsu, Shiro Tamura, Mikio Kanda1974 Volume 34 Issue 5 Pages 523-526
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSAn autopsy case of the malignant teratoma at the ovary in a 13 year old female.
This tumor was composed of cartilaginous, fatty tissue, and immature fibrous and glandular tissue. These immature tissue showed infiltrative or expansive proliferation into the surrounding tissue.View full abstractDownload PDF (4442K) -
Kazuhiko Soejima, Hidenori Ota, Shiro Tamura, Mikio Kando1974 Volume 34 Issue 5 Pages 527-532
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThree autopsy cases of duodenal carcinoma at the peripapillary portion, excluding those which arise in the pancreas, were found at the Showa University Hospital. These cases (67 yrs. Male, 79 yrs. Male and 43 yrs. Female) are adenocarcinoma, including a case which arise from aberrant of the pancreas (Heinrich I type) .View full abstractDownload PDF (8488K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1974 Volume 34 Issue 5 Pages 533-537
Published: October 28, 1974
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (585K)
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