脳刺激の心機能に及ぼす影響とくにThalamus及びHypothalamus刺激の心収縮能に及ぼす影響

抄録

It is widely known that various electrocardiographic changes are observed in patients suffering from various cerebral diseases. However, there still remain many unknown facts about how and why such changes occur.
In this study, the effect of electrical stimulation of the thalamus (nucl. medialis dorsalis : S group) and the hypothalamus (preoptic area : P group) of the dog brain on the cardiac function was investigated.
The parameters of the cardiac funtion studied were blood pressure, ECG, coronary boot flow, cardiac output along with the index of contractility, Vmax and max dp/dt.
A change in the ST·T segments on the ECG occurred in most cases just after the stimulation. The blood perssure, cardiac output and coronary blood flow appeared to change at about the same time. These changes were thought to be primary to stimulation for most cases. The appearance of the premature beats infrequently observed in both groups, esecially, in P group.
The heart rate increased after stimulation in S group, while there was a tendency for the heart rate to decrease in P grotp. The degree of change was slight in both groups. The blood pressure, cardiac output, Vmax and max dp/dt increased upon stimulation in S group.
However, with stimulation of P group, the parameters of these heart function tended to decrease. There seemed to be a close relation between Vmax and Vpm.
Therefore, it was thought that Vpm is the index of choice for the cardiac contractility.