1976 Volume 36 Issue 5-6 Pages 385-391
Liver function was examined in gastric ulcer patients under anesthesia who underwent gastric resection (Billroth's method) and who showed good general conditions by modified neuroleptoanesthesia (NLA) using Droperidol and Pentazocine.
Futher, liver function and liver tissue were examined in rabbits administered Droperidol and Pentazocine intravenously, and results obtained were compared with those in man.
Biochemically, there was noted a decline in serum total protein of man following anesthesia. Besides, no marked change in liver function was observed in both man and rabbit.
Microscopically, changes were noted up to 6 hours after anesthesia. On 24 hours, there was a tendency to recovery microscopically, but changes were still observable electron microscopically.
The effect of Droperidol and Pentazocine on the liver disappears with the lapse of time ; however, it is possible that these drugs will cause a transient change in liver cells.
