Abstract
The author studied the change of thrombelastogram (T. E. G.), coagulation time and cardiac output of the dogs anesthetized with pentobarbital sodium-nitrous oxide under controlled ventilation, followed by intravenous administration with escherichia coli endotoxin (3 mg/Kg) . Furthermore, the author studied the effects of methylprednisolone administration (30mg/Kg) prior to or after giving endotoxin and infusion of either low molecular weight dextran solution or lactated Ringen's solution (20ml/Kg) .
1. The prolongation of coagulation time and decrese of maximal amplitude were observed markedly in both treated group and non-treated group following administration with endotoxin on T. E. G. And also there was non-coagulation stiage.
2. The thrombin time, prothrombin time, partial thromboplastin time and plasma recalification time were prolonged markedly after administration with endotoxin in both treated group and non-treated group, and did not recover to the control value thoroughout observation period of three hours.
3. The improvement of coagulation time was observed early and better in methyl-prednisolone-treated group compared with the other group on T. E. G. Also in this graup, the prolongation of thromboplastin time, plasma recalcification time, thrombine time, and prothrombin time were very slight, especially in latter two tests.
4. In low molecular weight dextran infusion group, some coagulation ability remained 5 minutes after endotoxin administration, but there was on coagulation ability thirty minutes later. Thereafter, it recovered very good. The prolongation thrombin time was slight in this group like methylprednisolone-treated group.
5. The cardiac output, mean arterial blood pressure and central venus pressure were decreased by endotoxin administration. The low molecular dextran infusion was most effective to improve those parameters, followed by the group with treated methylprednisolone prior to endotoxin administration. But the latter was better than the former, considering the decrease of pH.
