Abstract
Changes of pulmonary function have been studied before, 30 minutes and 60 minutes during, and 30 minutes and 60 minutes after administration of ATP, trimetaphan (TM), and sodium nitroprusside (SNP) in 33 dogs anesthetized with pentobarbitone.
Results were as follows :
1. Right-to-left shunt increased during and after hypotension with TM, and during hypotension with ATP, but there was no statistical change. There was no change with SNP.
2. Physiological dead space increased during and after hypotension with TM, and its increase 30 minutes after hypotension with TM was significant statistically. It increased after hypotension with SNP. There was no significant change with ATP.
3. Mean pulmonary arterial pressure decreased during hypotension with ATP, TM, and SNP, after that, increased toward the control level with ATP, but tended to decrease with TM and SNP.
4. Cardiac output increased during hypotension with ATP and SNP, but decreased significantly 30 minutes during hypotension with TM.
5. Paco2 increased significantly 60 minutes during, and 30 minutes and 60 minutes after hypotension with TM, but there was no significant change with ATP or SNP.
6. Pao2 increased during hypotension with ATP and SNP, and further increased significantly after hypotension with SNP. On the other hand, it decreased during and after hypotension with TM.
7. Pvco2 increased significantly during and after hypotension with TM, but there was no significant change with ATP and SNP.
8. Pvo2 increased significantly during and after hypotension with ATP and SNP, but decreased transiently during hypotension with TM.
