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Volume 40 (1980)
- Issue 6 Pages 647-
- Issue 5 Pages 525-
- Issue 4 Pages 401-
- Issue 3 Pages 277-
- Issue 2 Pages 149-
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Volume 40, Issue 4
Displaying 1-14 of 14 articles from this issue
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[in Japanese], [in Japanese]1980 Volume 40 Issue 4 Pages 401-405
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
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[in Japanese]1980 Volume 40 Issue 4 Pages 407-413
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
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Hiroki SATO1980 Volume 40 Issue 4 Pages 415-422
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIn order to know the enzymic character of MAO in dog intestine, substrate specificities and effects of several inhibitors on MAO were studied. Homogenate (1: 4) of dog intestine was used as an enzyme source and MAO activity was measured manometrically with Warburg's apparatus. MAO in jejunum and ileum could oxidize tyramine most strongly, coming serotonin (5-HT) in the next, while oxidations of the other substrates, such as β-phenylethylamine (PEA), cadaverine, amylamine, histamine and benzylamine, were relatively weak. However, the substrate specificity of MAO in dog duodenum was varied in each experimental dogs. The substrate specificity of MAO in dog stomach was almost the same as that in small intestine. The MAO activities with tyramine and 5-HT in cardia were found to be significantly weaker than those in lesser curvature and pylorus. Clorgyline and harmine strongly inhibited MAO activities with 5-HT and tyramine as substrate, but slightly inhibited with PEA. On the other hand, deprenyl and pargyline did not inhibit MAO activity so strong whichever substrates was used. The affinity to oxygen of MAO in dog intestine was strong but no differences in affinities to oxygen of MAO were observed with any substrate used. From these results, it is suggested that there are two types of MAO in dog intestine such as type A and B MAO in liver, but type A MAO is predominant.View full abstractDownload PDF (942K) -
Hiroshi HASEGAWA, Shigeru TOMOYASHU1980 Volume 40 Issue 4 Pages 423-432
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSIt is inferred that biosynthesis of ceruloplasmin in liver is regulated by iron, copper and some hormones. In order to clarify the relationship between ceruloplasmin and iron metabolism, hypoceruloplasminemia and hypoferremia were made in rats fed by copper and iron deficient diets for two months.
Copper-deficient rats resulted in the deposition of iron in liver and spleen following by the decrease of ceruloplasmin and iron in serum and of apoceruloplasmin synthesis in liver. Serum iron of these rats returned to normal level with elevation of serum ceruloplasmin after intraperitoneal administration of copper sulfate. Iron-deficient rats showed a marked decrease of ceruloplasmin in serum in spite of increase of apoceruloplasmin synthesis in liver, while intraperitoneal administration of iron resulted in elevation of serum ceruloplasmin.
Biosynthesis of apoceruloplasmin was accelerated by administration of estrogen and testosterone, and was inhibited by intravenous administration of ceruloplasmin in normal rats.
The mucosal cells of rat duodenum deficient in copper are capable of taking up iron, but fail to release it to the plasma. The administration of ceruloplasmin to copper-deficient rats was followed by prompt increase in serum iron.
Ceruloplasmin appeared to be essential to the normal movement of iron from cells to plasma.View full abstractDownload PDF (2453K) -
Ken TAKAO1980 Volume 40 Issue 4 Pages 433-447
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSThe author studied the change of thrombelastogram (T. E. G.), coagulation time and cardiac output of the dogs anesthetized with pentobarbital sodium-nitrous oxide under controlled ventilation, followed by intravenous administration with escherichia coli endotoxin (3 mg/Kg) . Furthermore, the author studied the effects of methylprednisolone administration (30mg/Kg) prior to or after giving endotoxin and infusion of either low molecular weight dextran solution or lactated Ringen's solution (20ml/Kg) .
1. The prolongation of coagulation time and decrese of maximal amplitude were observed markedly in both treated group and non-treated group following administration with endotoxin on T. E. G. And also there was non-coagulation stiage.
2. The thrombin time, prothrombin time, partial thromboplastin time and plasma recalification time were prolonged markedly after administration with endotoxin in both treated group and non-treated group, and did not recover to the control value thoroughout observation period of three hours.
3. The improvement of coagulation time was observed early and better in methyl-prednisolone-treated group compared with the other group on T. E. G. Also in this graup, the prolongation of thromboplastin time, plasma recalcification time, thrombine time, and prothrombin time were very slight, especially in latter two tests.
4. In low molecular weight dextran infusion group, some coagulation ability remained 5 minutes after endotoxin administration, but there was on coagulation ability thirty minutes later. Thereafter, it recovered very good. The prolongation thrombin time was slight in this group like methylprednisolone-treated group.
5. The cardiac output, mean arterial blood pressure and central venus pressure were decreased by endotoxin administration. The low molecular dextran infusion was most effective to improve those parameters, followed by the group with treated methylprednisolone prior to endotoxin administration. But the latter was better than the former, considering the decrease of pH.View full abstractDownload PDF (3470K) -
Ken-ichi KAGAMI1980 Volume 40 Issue 4 Pages 449-459
Published: August 28, 1980
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSChanges of pulmonary function have been studied before, 30 minutes and 60 minutes during, and 30 minutes and 60 minutes after administration of ATP, trimetaphan (TM), and sodium nitroprusside (SNP) in 33 dogs anesthetized with pentobarbitone.
Results were as follows :
1. Right-to-left shunt increased during and after hypotension with TM, and during hypotension with ATP, but there was no statistical change. There was no change with SNP.
2. Physiological dead space increased during and after hypotension with TM, and its increase 30 minutes after hypotension with TM was significant statistically. It increased after hypotension with SNP. There was no significant change with ATP.
3. Mean pulmonary arterial pressure decreased during hypotension with ATP, TM, and SNP, after that, increased toward the control level with ATP, but tended to decrease with TM and SNP.
4. Cardiac output increased during hypotension with ATP and SNP, but decreased significantly 30 minutes during hypotension with TM.
5. Paco2 increased significantly 60 minutes during, and 30 minutes and 60 minutes after hypotension with TM, but there was no significant change with ATP or SNP.
6. Pao2 increased during hypotension with ATP and SNP, and further increased significantly after hypotension with SNP. On the other hand, it decreased during and after hypotension with TM.
7. Pvco2 increased significantly during and after hypotension with TM, but there was no significant change with ATP and SNP.
8. Pvo2 increased significantly during and after hypotension with ATP and SNP, but decreased transiently during hypotension with TM.View full abstractDownload PDF (1245K) -
Kenji MOCHIMARU1980 Volume 40 Issue 4 Pages 461-469
Published: August 28, 1980
Released on J-STAGE: November 19, 2010
JOURNAL FREE ACCESSPlatelet counts or function and hemodynamics in endotoxin shock were investigated in dogs. E. Coli endotoxin (3 mg/kg, LD100) was administrated intravenously to dogs which were anesthetized with pentobarbital and ventilated mechanically.
1) In all groups, platelet aggregation decreased 3 minutes after administration of Pndotoxin, which would be caused by decrease of platelet, thereafter increased.
2) Changes of platelet adhesion did not show any definite tendency. However, platelet adhesion decreased 3 minutes after administration of endotoxin with posttreatment of aspirin (50mg/kg), and after infusion of lactated Ringer's solution, but increased after infusion of low molecular weight dextran solution, and either pretreatment of methylprednisolone (30mg/kg) or posttreatment of methylprednisolone (30mg/kg) . The similar increase was observed in the control group received endotoxin alone.
3) All groups except the group received dextran solution showed marked decrease of platelet 3 minutes after administration of endotoxin, and then increase. The decrease of platelet which could be caused by trapping in lung did not cause the disturbance of gas exchange in lung. Therefore, a fall of Pao2, Paco2 and Pvo2 in early stage of shock, and a rise of Paco2 and Pvo2 in late stage of shock, appeared to result from reduced cardiac output and impairment of tissue perfusion.
4) FDP increased within 3 minutes after administration of endotoxin in all groups. Infusion of low molecular weight dextran solution or lactated Ringer's solution, and posttreatment of aspirin suppressed slightly increase of FDP. There was no relation among platelet counts, fibrinolysis and FDP.
5) Coucerning platelet, posttreatment of aspirin and pretreatment of methylprednisolone were effective. On the other hand, all therapies studied, especially low molecular weight dextran, improved circulatory state.View full abstractDownload PDF (1072K) -
Shohei TAKEDA1980 Volume 40 Issue 4 Pages 471-481
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSPulmonary function and hemodynamics in experimental endotoxin shock were studied in dogs. They were anesthetized by intravenous administration of pentobarbital and ventilated mechanically. Shock was caused by intravenous administration of E. Coli endotoxin (3 mg/kg LD100) . Dogs were divided in three groups as follows.
Group 1 (G-1) ; administration of Et, alone, Group 2 (G-2) ; posttreatment with aspirin (75mg/kg) after administration of Et. as in Group 1, Group 3 (G-3) ; posttreatment with low molecular weight dextran solution (20ml/kg) after adminstration of Et. as in Group 1.
1) A-aDo2 increased in the same degree in both G-1 and G-2, but it increased in the latter more than in the former 120 minutes after administration of Et. On the contrary, in G-3 it decreased markedly 60 minutes after the administration of Et.
2) The pattern of increase in a-ADn2 was similar in G-2 and G-1. However in G-3, a-ADn2 decreased following infusion and this tendenccy unchanged throughout the experiment.
3) Closing volume increased gradually in G-1. In G-3 the increase was very slight for 120 minutes, but it increased significantly 180 minutes after administration of Et. and its increase was most marked among three groups.
4) FRC showed little change in both G-1 and G-2. On the other hand, it increased gradually in G-3, though its increase was very slight.
5) Pao2 fell gradually and slightly in G-2 compared with G-1, but in G-3 it increased slightly as compared with control value throughout the study.
6) G-2 showed the best results among three groups in the degree of recovery in mean arterial pressure, base beficit and pHa. On the other hand, G-3 was best in the recovery of central venous pressure for 180 minutes and the cardiac output for 60 minutes after the administration of Et.
In conclusion, both the intravenous administration of aspirin and low molecular weight dextran solution were similarly effective in circulatory changes caused by Et., while the latter was superior to the former as for the alternation of the pulmonary functions.View full abstractDownload PDF (1312K) -
Takuo SAKURAYAMA1980 Volume 40 Issue 4 Pages 483-492
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSBlood viscosity and hemodynamics in endotoxin shock were studied in dogs. E. Coli endotoxin (3 mg/kg LD100) was administrated intravenous to dogs which were anesthetized with pentobarbital and ventilated mechanically.
Blood viscosity decreased in posttreatment with low molecular weight dextran solution (20 ml/kg) after administration of Et. (D-group) . But in another groups-administration of Et. alone (A-group), pre and posttreatment with methilpredonisolon (30 mg/kg) before and after administration of Et. (B, C-group) posttreatment with Lactated Ringer's solution (20 ml/kg) after administration of Et. (E-group) -similar increase was observed.
In all groups, hematocrit increased with the advance of shock, however in B group, the rate of increase was lower than D group. There is no interrelation between blood viscosity and hematocrit was observed.View full abstractDownload PDF (1234K) -
Masataka CHISAKA1980 Volume 40 Issue 4 Pages 493-500
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSWe discussed the effects on the circulation and acid base balance of the dog when elective haemodilution is done with the use of gelatine haemaccel solution, which is colloidal solution. There is an increase in cardiac output and decrease in total protein when gelatine haemaccel solvent just as Lactate Ringer's solution, Dextran, or Hydroxyethyl starch is used. The amount of gelatine haemaccel solution which transfuses to maintain the circulation was 1.2 times as much as the blood removed.
When we dilute the hematocrit down to ten per cent, the martality rate increased and the metabolic acidosis progressed.
Therefore, we should consider that the critical point for dilution of hematocrit is from twenty to twenty-five per cent.
Retransfusing the blood after hemodilution, the circulatory system will normalize ; however, the recovery of hemoglobin and hematocrit was not sufficient.View full abstractDownload PDF (800K) -
Motoji SUZUKI, Katsuko KIMURA, Nobuhiko KOMATSU1980 Volume 40 Issue 4 Pages 501-506
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSNeutrophil chemotaxis and NBT test were used to demonstrate the effect of schizophyllan (SPG) on the phagocytosis by neutrophils.
(1) Neutrophil migration test in Boyden chamber
SPG proved to exert the highest chemotactic activity on mouse neutrophils at the concentration of 10 μg/ml.
When neutrophils from SPG-treated mice were employed, the stimulation of migratory capacity could be observed from 16 hours and maintained for more than 30 days after the intramuscular administration of 1 or 10 mg/kg of SPG.
(2) NBT test
SPG showed the strongest activity on NBT-reduction at the concentration of 10 μg/ml.
When neutrophils from SPG-treated mice were tested, the NBT-reduction activity began to increase from 1 hour, reached a peak on the 10 th day, and then decreased to the normal level 20 days after the intramuscular injection of 1 or 10 mg/kg of SPG.
SPG is considered to contribute to the phagocytosis by stimulating the chemotactic and NBT-reduction activities of neutrophils both in vitro and in vivo.View full abstractDownload PDF (620K) -
Ken-ichi KAGAMI, Kazuyuki SERATA, Masanao SHIBUYA, Ryo YATSUSHIRO, Shi ...1980 Volume 40 Issue 4 Pages 507-510
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSTinnitus and feeling fullness of the ear as attendant symptoms on sudden deafness are important problem on treatment, as same as the sense of hearing. We investigated the effects of stellate ganglion block for tinnitus and feeling fullness of the ear with a questionnaire. Patients were 22 men and 18 wemen who were from 11 to 76 years old.
At the first medical examination, the many patients had complaints of tinnitus and feeling fullness of the ear. After treatment with stellate ganglion block, for tinnitus, 77 % of fresh type were vanished it or get better it, and 54% of stale type were get better, too. On the other hand, it was good results for feeling fullness of the ear, the same as tinnitus. Stellate ganglion block is the effective treatment for tinnitus and feeling fullness of the ear at sudden deafness.View full abstractDownload PDF (367K) -
Juzo TAKEDA, Hiroshi MATSUZAKI, Chikatsu ISHII, Shigeaki YAMAOKA, Masa ...1980 Volume 40 Issue 4 Pages 511-516
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSChoriocarcinoma derived from the pregnancy previous to the delivery is found a little more often in Europe and America than in Japan as indicated in the incidence of 7.3 to 37.1%. Different from the management of hydatidiform mole, choriocarcinoma is very difficult in the corresponding control and, further, it has a tendency to increase in the incidence, compared with choriocarcinoma following the hydatidiform mole. To explain the pathogenesis of this cancer, the following can be considered : (1) The outbreak due to the villus of a retained placenta, (2) The onset of primary choriocarcinoma in a normal placenta at the end of pregnancy period. For detecting the cancer, there are no other methods than the scrutiny of the placenta at delivery and the notice of an abnormal postpartum bleeding.
Two cases lately experienced were non-metastatic choriocarcinoma after the delivery, detected in a comparatively early stage. The chemical treatment with the use of both methotrexate and actinomycin D was conducted for these patients before the excision of the uterus.
In both cases, no abnormalities have been found for 15 months and 9 months after the operation respectively. On this occasion, our views on choriocarcinoma derived from the pregnancy previous to the delivery have been described, based on the actual experience and the knowledge through the literature.View full abstractDownload PDF (4222K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1980 Volume 40 Issue 4 Pages 517-524
Published: August 28, 1980
Released on J-STAGE: September 09, 2010
JOURNAL FREE ACCESSDownload PDF (1100K)
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