Abstract
Specific IgG and IgE antibodies were determined in 101 asthmatic children during the course of immunotherapy with allergen extracts of mite, silk and alternaria. The results were studied in relation to the clinical improvement of the patients.
In each antigen IgG antibodies showed high levels when the concentration of the extracts were great enough to reach maintenance dose, and the duration of the therapy was sufficiently long. No significant changes could be seen in respect to IgE antibodies.
IgG antibodies showed remarkably higher levels in the group of patients reporting excellent clinical effect, while they showed lower levels in the “improving” group, “unchanged” or “worse” group and “controlled ”, group as well.
IgG antibodies increased about six months after initiation of immunotherapy.
No significant correlations could be found between IgE antibodies and the clinical symptoms of the patients.
