Abstract
The present work is an attempt to measure the lipid preoxide, C-reactive protein, rheumatoid factor value as a parameter of peroxidation by 1O2 and to measure the activities of Vitamin E as scavenger in the serum and synovial fluid of patient with rheumatoid arthritis and osteoarthritis. The following result were obtained. (1) Vitamin E value of the synovial fluid in the rheumatoid arthritic group was found to be higher than that in osteoarthritic group, whereas in the serum no significant difference was found between two groups. (2) Lipid peroxide value of the synovial fluid in the rheumatoid arthritic group was found to be higher than that in osteoarthritic group. (3) A significant correlation was also found between the vitamin E, the lipid peroxide value and inflamatory indexes such as C-reactive protein in the synovial fluid in rheumatoid arthritic group. These observation suggests that free radical materials may play an important role as a chemical mediation on the inflammatory responce of rheumatoid arthritis and that vitamin E may play a role as a chemical mediater on the anti-inflammatory responce.
