Journal of The Showa Medical Association
Online ISSN : 2185-0976
Print ISSN : 0037-4342
ISSN-L : 0037-4342
THE SERIAL CHANGE OF AMYLASE AND AMYLASE ISOZYME IN THE BODY FLUID ON LAPAROTOMY
—The investigation of amylase isozyme and ACCR—
Toshihiro SAKURAIYasushi TAKAGI
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JOURNALS FREE ACCESS

1988 Volume 48 Issue 2 Pages 233-238

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Abstract

Serial changes of amylase and amylase isoenzyme in body fluid before and after laparotomy were investigated in 50 patients. Serum amylase activity was diminished 1 to 3 hr after operation and was elevated at 12 hr. Total activity reached a maximum at 24 hr postoperative (24 hr preoperative baseline is 2.78±0.53 (X±SE) ) . Thereafter, serum amylase activity decreased gradually to baseline after 3 to 5 days postoperative. Meanwhile pancreatic P-amylase did not change significantly from preoperative levels. In contrast, fluctuation of S-amylase from the salivary glands and intestines was similar to that of the total activity, suggesting that transient hyperamylasemia after laparotomy is attributable to S-amylase activity. There was no direct relation between hyperamylasemia and operative time or target disease. This suggests that the elevation of serum amylase activity is mediated by a nonspecific mechanism. The 24 hr postoperative amylase-creatinine clearance ratio (ACCR) was 4.43±1.55 (%) . This was significantly (p<0.05) higher than the preoperative level of 3.73±1.0 (%) (X±SD) . In particular, the ACCR of S-amylase compared with that of P-amylase was not elevated. showing that this could be a factors in postoperative hyperamylasemia.

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