Abstract
The influence of exogenous gastrin on healing of gastric ulcer in rat experimentally produced by the injection of 20% acetic acid in rats was studied. The rats with ulcer were divided into four groups. Group C received saline subcutaneously, group G received 250μg/kg of pentagastrin subcutaneously, group O received 20mg/kg of omeprazol orally and G + O group received both pentagastrin subcutaneously and omeprazol orally. The rats were examined 1, 3, 5, 7 and 10 days after the experimental production of ulcer. The labelling index of cells by BrdU in the ulcer margin was significantly higher in group G than in group C at 3, 5 and 7 days, and in the G + O group than in group O at 3 and 5 days. However, the labeling index in G + O group was significantly lower than in group O at 7 and 10 days. Suppression of capillary formation and fibrosis in the fundus of the ulcer was histologically observed in group G and G + O group. These results suggest that the administration of exogenous gastrin stimulates the regeneration of gastric mucosa of the ulcer margin at the early stage of ulcer healing, but suppresses capillary formation and fibrosis in the connective tissue of the ulcer fundus.
