Abstract
Few studies of the biological specificity of pediatric malignant teratomas have been perf omed because of their various origins and classifications. A pediatric yolk sac carcinoma was successfully transplanted to BALB/c nude mice. Tumors in nude mice exhibited the characteristics and DNA ploidy pattern of the original tumor and were able to synthesise alpha-fetoprotein. We investigated sensitivity of the transplanted tumor to anticancer drugs within vitroMTT assay andin vivoexperimental chemotherapy administered by intraperitoneal injection. Results of tests for sensitivity were as follows.
1) 5-Fluorouracil (5-FU) was not effective against the tumors.
2) Cis-diamminedichloroplatinum (II) (CDDP) was most effective.
3) Pirarubicin hydrochloride (THP-ADM) was effective on MTT assay but not effective on thein vivotest.
Pediatric yolk sac carcinomas transplanted to nude mice exhibit the characteristics and chemosensitivity of the original tumor and are very useful in studies of biological specificity.
