Abstract
The effects of mizoribine on protective immunity againstHymenolepis nanawere examined in male AKR mice. Mizoribine suppressed the development of protective immunity againstH. nanareinf ection when administered orally to mice as 600mg/kg doses three times per day.
Oral administration of mizoribine to mice infected withH. nanadecreased footpad thickness in response to intradermal injection with egg antigen.
Oral administration of 1800 mg/kg (600 mg/kg 3 times per day) mizoribine also suppressed3H-thymidine uptake by mesenteric lymph node cells that had been prepared from mice 3 hours after the final drug administration and cultured for 2 hours in the presence of 37 kBq of3H-thymidine.
These results suggest that mizoribine inhibits lymphoblastic activityin vivoand prevents the development of protective immunity.
