Abstract
Cell proliferation, cell adhesion and tumor suppressor gene for actinic keratosis (AK), keratoacanthoma (KA), Bowen disease and squamous cell carcinoma (SCC) were studied. The expressions of Ki-67 and p53 were significantly different between AK and Bowen disease and between KA and SCC. The expressions of E-cadherin was also significantly different not only between AK and Bowen disease and between KA and SCC, but also between Bowen disease and SCC. These results appear to indicate that when evaluating malignancy, knowledge of Ki-67 and p53 expressions is useful for differential diagnosis between AK and Bowen disease and between KA and SCC. In addition, evaluation of E-cadherin expression appears useful for differential diagnosis not only of AK versus Bowen disease and KA versus SCC, but also of Bowen disease versus SCC.
