ナノ・マイクロデバイスによるがんの超早期診断

抄録

Nanobiodevice is a piece of contrivance, equipment, machine, or component, which is created by the overlapping multidisciplinary activities associated with nanotechnology and biotechnology, intended for biological, medical, and clinical purposes. In this lecture, I will describe the development of nanobiodevices for biomedical applications, including single cancer cell diagnosis for cancer metastasis, circulating tumor cell (CTC) detection by microfluidic devices, nanopillar devices for ultrafast analysis of genomic DNA and microRNA, nanopore devices for single DNA and microRNA sequencing, nanowire devices for exosome analysis, single-molecular epigenetic analysis for very early diagnosis for cancer. Y. Baba, et al., Chem. Soc. Rev., 39, 948 (2010); Nature Biotech., 22, 337 (2004); Nature Biotech., 22, 1360 (2004); ACS Nano., 4, 121 (2010); ACS Nano., 5, 493, (2011); ACS Nano, 5, 7775 (2011); ACS Nano, 5, 9264 (2011); Nano Lett., 12, 6145 (2012); Nucleic Acids Res., 40, 284 (2012); ACS Nano, 7, 3029 (2013); Nano Lett., 13, 1877 (2013); Sci. Rep. (Nature Pub. Group), 4, 5252 (2014); Lab on a Chip, in press (2015).