Abstract
Neural axons can change their conduction properties in response to the preceding activity, which is suggested to have an important role in neural information processing. However, little is known about the relationship between firing frequency and following changes due to a lack of appropriate techniques. In this study, we developed a novel microfabricated device to record evoked responses of multiple axons simultaneously. Rat cortical neurons were cultured and their axons were stimulated from a stimulating electrode. The recovery time and frequency-dependent changes were evaluated from the responses. The results suggest that the device is feasible to study computational capacity of axons.
