Abstract
We have ever proposed the method of active control of microbubbles under ultrasound exposure for the future drug delivery system. Recently we adopted bubble liposomes (BLs) because they can contain various kinds of drug. However it has problems in BLs, which are easy to destruct under ultrasound exposure. First we have found the appropriate parameters of ultrasound to suppress the destruction indices of BLs in a flow circuit including artificial blood vessel. Evaluation method of BLs is concentration using brightness on echograms. We succeeded to induce BLs with maximum induction index of 79 %, where destruction index of 30 % was acceptable.
